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Bone Metabolism Effects of Medical Therapy in Advanced Renal Cell Carcinoma.

Author: BarnabeiAgnese, CorselloAndrea, CorselloSalvatore Maria, IannantuonoGiovanni Maria, LocantorePietro, ParagliolaRosa Maria, TorinoFrancesco

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study examines the potential effects of tyrosine kinase inhibitors (TKI) and immune-checkpoint inhibitors (ICI), used in advanced renal cell carcinoma (RCC) treatment, on bone metabolism. The study highlights the risk of hypophosphatemia, hypocalcemia, and osteonecrosis of the jaw associated with these therapies.
Paper Details　
Original Abstract of the Article :
The medical therapy of advanced renal cell carcinoma (RCC) is based on the use of targeted therapies, such as tyrosine kinase inhibitors (TKI) and immune-checkpoint inhibitors (ICI). These therapies are characterized by multiple endocrine adverse events, but the effect on the bone is still less know...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856493/

データ提供：米国国立医学図書館（NLM）

Bone Metabolism and Advanced Renal Cell Carcinoma: A Complex Interplay

The study of advanced renal cell carcinoma (RCC) is like exploring a vast, complex desert, filled with challenges and potential pitfalls. This research examines the impact of medical therapies for advanced RCC on bone metabolism, a critical aspect of overall patient health. The authors highlight the potential for both targeted therapies and immune-checkpoint inhibitors (ICI) to cause a range of endocrine adverse events, including those affecting bone. The study underscores the importance of monitoring bone metabolism in patients receiving these therapies to minimize the risk of complications.

Navigating the Sands of Bone Health: A Comprehensive Approach to Managing RCC

The study emphasizes the importance of a comprehensive approach to managing advanced RCC, with a focus on both tumor control and bone health. It highlights the potential for medical therapies to impact bone metabolism and emphasizes the need for careful monitoring to identify and manage potential complications. The study's findings underscore the importance of collaboration between oncologists and other healthcare professionals to optimize patient care.

Maintaining Bone Health: Essential Considerations for RCC Treatment

This research provides valuable insights for patients with advanced RCC and their healthcare providers. It highlights the importance of monitoring bone metabolism, particularly in the context of targeted therapies and ICI. It also underscores the need for a multidisciplinary approach to managing this complex disease, ensuring comprehensive care and addressing potential side effects related to bone health.

Dr. Camel's Conclusion

The study's examination of bone metabolism in advanced RCC provides a valuable map for navigating the complexities of this disease. It highlights the importance of a multidisciplinary approach to care, focusing on both tumor control and bone health. By carefully monitoring bone metabolism and implementing appropriate interventions, we can help improve the overall well-being of patients with advanced RCC.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-03-28
Further Info :

Pubmed ID

36672478

DOI: Digital Object Identifier

PMC9856493

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Languages

English

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