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[Combined drug treatment of far-advanced forms of breast cancer].

Author: BorisovA I

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 70 patients with advanced breast cancer compared two treatment regimens: chemotherapy alone and chemotherapy plus ovariectomy with hormone therapy. The chemotherapy regimen included vincristine, 5-fluorouracil, methotrexate, cyclophosphamide, and prednisolone. Chemotherapy alone achieved objective responses in 71.4% of patients, with a median remission duration of 7.6 months. The group receiving chemotherapy plus ovariectomy and hormone therapy had an 88.5% objective response rate with a median remission duration of 10.7 months. Both regimens were effective in treating primary tumors and regional lymph node metastases, but less effective in treating lung and pleural metastases. No serious treatment-related complications were reported.
Paper Details　
Original Abstract of the Article :
Seventy patients with breast cancer (stage IIIb--IV) were randomized by an "envelope" method into 2 groups, each including 35 persons. Patients of the first group were injected vincristin, 5-fluoruracil, methotrexate (once a week), cyclophosphane (3 times a week) and prednisolone daily during 3 week...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/366897

データ提供：米国国立医学図書館（NLM）

Fighting Breast Cancer: A Combined Approach

This research delves into the effectiveness of a combined drug therapy regimen for advanced breast cancer (stages IIIb-IV). The study involved 70 patients randomly assigned to two groups. The first group received a combination of chemotherapy drugs (vincristin, 5-fluoruracil, methotrexate, cyclophosphane, and prednisolone), while the second group received the same chemotherapy regimen plus ovariectomy and continuous prednisolone, testosterone-propionate, or synoestrol administration. The results indicate that both groups showed significant objective improvement, with the second group experiencing a slightly higher response rate and longer remission duration. The study highlights the potential benefits of combining chemotherapy with ovariectomy and hormonal therapy in treating advanced breast cancer.

Combating Cancer: Collaboration and Innovation

The study demonstrates the effectiveness of a combined approach to breast cancer treatment, combining chemotherapy, surgery, and hormonal therapy. It's like navigating a treacherous desert landscape – a multi-faceted approach is necessary to overcome the challenges and achieve success. This finding underscores the importance of ongoing research and collaboration in developing innovative cancer therapies that cater to the unique needs of each patient.

Strength in Unity: A Multi-Disciplinary Approach to Cancer Care

The desert is a landscape of extremes, and treating cancer requires a similar multi-disciplinary approach, bringing together expertise from various fields. This study underscores the importance of collaboration between oncologists, surgeons, and other healthcare professionals in developing personalized treatment plans for patients with advanced breast cancer. By working together, we can overcome the challenges and achieve positive outcomes for those battling this disease.

Dr.Camel's Conclusion

This study showcases the power of a multi-pronged approach to treating advanced breast cancer. It's like finding a hidden oasis in the desert – a place of healing and hope. This research encourages us to stay informed about the latest advancements in cancer treatments and to advocate for personalized approaches that prioritize the individual patient's needs. Just as the desert holds a diverse array of life, we must recognize the unique complexities of cancer and harness the power of collaboration to overcome this challenging disease.

Date :
  1. Date Completed 1979-03-13
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

366897

DOI: Digital Object Identifier

366897

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Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

Russian

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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