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Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial.

Author: BansalSumit, PaineMary F, SpindleTory R, SurujunarainRenuka, UnadkatJashvant D, VandreyRyan, WeertsElise M, ZamarripaC Austin

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study highlights the need for research into the pharmacokinetics and pharmacodynamics of cannabis extracts with varying Δ9-THC and CBD concentrations. Previous studies have shown that CBD can influence the effects of Δ9-THC, but no studies have evaluated the differences in PK and PD between orally administered cannabis extracts with varying concentrations.
Paper Details　
Original Abstract of the Article :
Controlled clinical laboratory studies have shown that cannabidiol (CBD) can sometimes attenuate or exacerbate the effects of Δ9-tetrahydrocannabinol (Δ9-THC). No studies have evaluated differences in pharmacokinetics (PK) of Δ9-THC and pharmacodynamics (PD) between orally administered cannabis extr...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926328/

データ提供：米国国立医学図書館（NLM）

CBD's Influence on THC: A Desert Oasis of Pharmacokinetic Exploration

The study delves into the complex interplay between [cannabidiol (CBD)] and [Δ9-tetrahydrocannabinol (Δ9-THC)], two key components of cannabis. The authors, like explorers traversing the desert of cannabinoid research, sought to understand how CBD affects the [pharmacokinetics (PK)] and [pharmacodynamics (PD)] of Δ9-THC when administered orally. Their research aimed to shed light on the potential for CBD to [attenuate or exacerbate] the effects of Δ9-THC, providing valuable insights into the potential therapeutic applications of these compounds.

Unveiling the Interplay of CBD and THC

The study found that [CBD] can influence the [PK and PD] of [Δ9-THC] when administered orally. This finding, like a well-hidden oasis in the desert, suggests that the effects of cannabis products may vary depending on the [ratio of CBD to Δ9-THC]. The authors' research highlights the importance of [carefully considering the composition] of cannabis extracts when exploring their potential therapeutic benefits.

Navigating the Desert of Cannabis: A Guide for Consumers

This research emphasizes the importance of [understanding the complex interplay] between CBD and Δ9-THC. Consumers of cannabis products should be aware that the [effects] of these products can vary depending on the [ratio of these cannabinoids]. It's always advisable to consult with a healthcare professional to discuss the appropriate use of cannabis products, especially when considering their potential therapeutic benefits.

Dr. Camel's Conclusion

The desert of cannabis research is a vast and complex landscape. This study serves as a reminder that the [effects] of cannabis products can be influenced by the [interaction] of their various components. Like a skilled desert navigator, we must carefully consider the complexities of cannabis before embarking on its potential therapeutic journey.

Date :
  1. Date Completed 2023-02-15
  2. Date Revised 2023-03-10
Further Info :

Pubmed ID

36780161

DOI: Digital Object Identifier

PMC9926328

Related Literature

Article Analysis
・Effects of cannabidiol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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