Efficacy, safety and indirect comparisons of lasmiditan, rimegepant, and ubrogepant for the acute treatment of migraine: A systematic review and network meta-analysis of the literature.

Author: GoadsbyPeter J, HaghdoostFaraidoon, HuesslerEva-Maria, LisickiMarco, PuleddaFrancesca, TassorelliCristina, YounisSamaira

Paper Details 
Original Abstract of the Article :
BACKGROUND: We performed a random-effects network meta-analysis to study the efficacy and safety of newly developed drugs for the acute treatment of migraine attacks. METHODS: MEDLINE via PubMed, Embase and The Cochrane Register of Controlled Trials were searched from inception to 11 February 2022....See full text at original site
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引用元:
https://doi.org/10.1177/03331024231151419

データ提供:米国国立医学図書館(NLM)

Finding the Right Treatment for Migraine Attacks

Migraine, a debilitating neurological disorder characterized by severe headaches, can feel like a relentless desert storm, leaving sufferers feeling lost and incapacitated. This study explores the efficacy and safety of three newly developed drugs for the acute treatment of migraine attacks: lasmiditan, rimegepant, and ubrogepant. The researchers used network meta-analysis to compare these drugs, evaluating their effectiveness and side effect profiles.

Comparing Migraine Treatment Options: Finding the Right Fit

The study found that lasmiditan was the most effective drug for treating migraine attacks, but it was also associated with higher rates of dizziness, nausea, and somnolence. Rimegepant showed slightly lower but similar efficacy rates to lasmiditan. Ubrogepant, on the other hand, had the best tolerability profile. While the study highlights the potential benefits of these newer migraine treatments, it also underscores the importance of individual patient factors and the need to carefully consider the potential benefits and risks of each drug.

Finding Relief from Migraine: A Personalized Approach

This study provides valuable insights into the evolving landscape of migraine treatment, offering a wider range of options for patients seeking relief from this debilitating disorder. The findings emphasize the importance of a personalized approach to migraine management, considering the specific needs and preferences of each patient. As we continue to explore the intricate world of migraine, we must embrace a patient-centered approach, ensuring that individuals have access to the most effective and safe treatments available.

Dr. Camel's Conclusion

Migraine, a relentless desert wind that can whip up a storm in the brain, can leave sufferers feeling lost and desperate for relief. This study, like a cool oasis in the midst of the desert, offers valuable insights into the effectiveness and safety of newer migraine treatments. The findings provide a guide for navigating the complexities of migraine management, empowering both patients and clinicians to make informed decisions. As we continue to journey through the landscape of migraine research, we must remain committed to finding innovative and effective solutions for all those affected by this debilitating disorder.

Date :
  1. Date Completed 2023-02-15
  2. Date Revised 2023-02-16
Further Info :

Pubmed ID

36786357

DOI: Digital Object Identifier

10.1177/03331024231151419

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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