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Comparison of two doses of cimetidine and placebo in the treatment of duodenal ulcer: a multicentre trial.

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Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Cimetidine was effective in healing duodenal ulcers. In a double-blind multicentre trial, 61% of patients on 1 g cimetidine daily and 70% of patients on 2 g cimetidine daily showed complete ulcer healing after 4 weeks compared to 28% of those on placebo.
Paper Details　
Original Abstract of the Article :
Endoscopy, clinical assessment, and laboratory studies were used to compare, in a double-blind multicentre trial, the effects on patients with duodenal ulceration of treatment for four weeks by either placebo or 1 g/day cimetidine, or 2 g/day cimetidine. Ulcer healing occurred in 28% of patients on ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1136/gut.20.1.68

データ提供：米国国立医学図書館（NLM）

Cimetidine: A Dose-Effective Treatment for Duodenal Ulcers

The realm of [gastroenterology] is constantly searching for effective treatments for [duodenal ulcers]. This study investigates the efficacy of [cimetidine] in treating this condition. The authors conducted a [double-blind multicentre trial] to compare the effects of [placebo], [1 g/day cimetidine], and [2 g/day cimetidine] on patients with [duodenal ulceration]. Their findings demonstrate that [cimetidine conferred an advantage over placebo, but the effects of the two doses of cimetidine were not shown to be different] and that [1 g is a suitable daily dose of cimetidine for the treatment of duodenal ulceration].

A Dose of Relief: Cimetidine and Duodenal Ulcers

This study confirms the effectiveness of [cimetidine] in treating [duodenal ulcers]. The findings indicate that a [1 g daily dose] provides significant relief from [symptoms] and promotes ulcer healing.

Soothing the Stomach's Desert: Cimetidine and Duodenal Ulcers

Imagine a camel traversing a desert with a burning thirst, searching for a source of relief. This research explores how [cimetidine] can soothe the discomfort of [duodenal ulcers], providing a much-needed dose of relief. The findings suggest that [cimetidine] is an effective and well-tolerated treatment option for this condition.

Dr.Camel's Conclusion

The findings of this study provide valuable insights into the effective treatment of [duodenal ulcers]. The use of [cimetidine] at a [1 g daily dose] offers a safe and effective way to manage this condition, providing much-needed relief from the discomfort of [ulceration]. Just as a camel relies on its hump for sustenance, patients can rely on [cimetidine] to provide a source of relief and support during their recovery.

Date :
  1. Date Completed 1979-04-25
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

367885

DOI: Digital Object Identifier

10.1136/gut.20.1.68

Related Literature

Article Analysis
・Effects of cimetidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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