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Effectiveness and safety of tenofovir alafenamide in children and adolescents living with HIV: a systematic review.

Author: CastroHannah, CollinsIntira Jeannie, JessonJulie, JuddAli, LeroyValériane, MilanziEdith, O'RourkeJohn, PenazzatoMartina, RenaudFrançoise, TownsendClaire L, VicariMarissa

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tenofovir alafenamide (TAF)-containing regimens showed good viral suppression and no obvious safety concerns in children and adolescents living with HIV over 24-48 weeks. However, further research is needed to assess long-term safety and efficacy in this population.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Tenofovir alafenamide (TAF) is approved for paediatric use in fixed-dose combination tablets, but efficacy and safety data in children are limited. We conducted a systematic review on the efficacy/effectiveness and safety of TAF in infants, children and adolescents living with HIV. ME...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950035/

データ提供：米国国立医学図書館（NLM）

Tenofovir Alafenamide: A Promising Treatment for HIV in Children and Adolescents

This study delves into the world of HIV treatment, specifically focusing on the efficacy and safety of tenofovir alafenamide (TAF) in children and adolescents. Researchers conducted a systematic review of existing literature to evaluate the effectiveness of TAF in managing HIV in younger patients. They aimed to understand the potential benefits and risks associated with this medication for this vulnerable population.

TAF: Effective and Safe for Children and Adolescents

The review found that TAF showed good viral suppression in both treatment-naïve and treatment-experienced children and adolescents with HIV. Researchers observed high rates of viral suppression, indicating that TAF is effective in controlling HIV infection in younger patients. The study also found that TAF was generally well-tolerated, with a low incidence of adverse events. These findings suggest that TAF could be a safe and effective treatment option for children and adolescents with HIV.

Navigating HIV Treatment for Children and Adolescents

This research emphasizes the importance of tailoring treatment plans for children and adolescents living with HIV. It highlights the need for further investigation into the long-term safety of TAF, particularly regarding metabolic changes and weight management. Just as a desert plant adapts to harsh conditions to thrive, pediatric patients require careful monitoring and adjustment of treatment plans to ensure their well-being.

Dr.Camel's Conclusion

This study underscores the crucial importance of safe and effective treatment options for children and adolescents living with HIV. It's a reminder that research continues to advance, offering hope for a better future for these young patients. The findings regarding TAF are encouraging, but further research is needed to understand its long-term impact. It's a journey towards a healthier future, and we must continue to explore and innovate to find the best solutions for children and adolescents battling HIV.

Date :
  1. Date Completed 2023-02-27
  2. Date Revised 2023-03-15
Further Info :

Pubmed ID

36823283

DOI: Digital Object Identifier

PMC9950035

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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