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Nabumetone kinetics in the young and elderly.

Author: FittsD A, McMahonF G, RyanJ R, VargasR

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Nabumetone, a nonsteroidal anti-inflammatory drug, showed similar pharmacokinetic profiles in young and elderly individuals. The drug did not accumulate with daily dosing, and elderly patients may require a lower dose due to differences in elimination.
Paper Details　
Original Abstract of the Article :
Nabumetone, a nonsteroidal anti-inflammatory drug of the naphthylalkanone class, was studied in an open-label fashion to compare the relative single-dose and steady-state kinetics in young healthy male volunteers and in elderly patients with degenerative joint disease. Seventeen healthy male volunte...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9343(87)90603-6

データ提供：米国国立医学図書館（NLM）

Nabumetone: A Closer Look at Its Effects in Different Age Groups

Nabumetone, a nonsteroidal anti-inflammatory drug (NSAID), is widely used to manage pain and inflammation. This research explores the pharmacokinetic differences in nabumetone between young and elderly individuals. The study involved both healthy young volunteers and elderly patients with degenerative joint disease. The results showed that elderly patients had a significantly slower elimination rate of nabumetone compared to younger individuals, suggesting that they might require lower doses of the drug. The study also highlights the importance of considering age-related differences in drug metabolism and elimination when prescribing medications.

Age-Related Differences in Nabumetone Pharmacokinetics

The study highlights significant differences in nabumetone pharmacokinetics between young and elderly individuals, with elderly patients exhibiting a slower elimination rate. These findings underscore the importance of tailoring medication dosages based on age-related factors.

Personalized Medicine: Adapting Treatment to Individual Needs

The study emphasizes the need for personalized medicine, adapting treatment regimens to the unique characteristics of each patient. Considering age-related differences in drug metabolism and elimination is crucial for ensuring safe and effective medication use.

Dr.Camel's Conclusion

This research reminds us that the desert of healthcare is filled with diverse landscapes, and each individual's journey through it is unique. Understanding age-related differences in drug metabolism is crucial for navigating this terrain and ensuring the best possible outcomes for all.

Date :
  1. Date Completed 1987-12-23
  2. Date Revised 2019-06-26
Further Info :

Pubmed ID

3688002

DOI: Digital Object Identifier

10.1016/0002-9343(87)90603-6

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SNS
PICO Info
in preparation
Languages

English

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