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Reverse Engineering Drugs: Lorcaserin as an Example.

Author: PreskornSheldon H, Schwasinger-SchmidtTiffany

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study highlights the use of reverse engineering in drug development to produce novel central nervous system (CNS)-based therapies with enhanced efficacy and reduced toxicities. The development of lorcaserin, a specific 5HT<sub>2C</sub> serotonin receptor agonist for obesity, exemplifies this approach by limiting off-target effects and reducing hallucinogenic and cardiovascular side effects. Reverse engineering reduces costs, identifies targeted patient populations, and produces therapies with greater efficacy and limited toxicity.
Paper Details　
Original Abstract of the Article :
Novel central nervous system (CNS)-based therapies have been difficult to produce due to the complexity of the brain, limited knowledge of CNS-based disease development and associated pathways, difficulty in penetrating the blood brain barrier, and a lack of reliable biomarkers of disease. Reverse e...See full text at original site
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引用元：
https://doi.org/10.1007/978-3-031-21054-9_8

データ提供：米国国立医学図書館（NLM）

Reverse Engineering Drugs: A New Era in CNS Therapy

The development of [central nervous system (CNS)] therapies has long been hindered by the complexity of the brain. This study explores the innovative approach of [reverse engineering] in drug development, using [lorcaserin] as a prime example. The authors highlight how [reverse engineering] allows researchers to leverage new knowledge of disease pathways and develop medications with enhanced efficacy and reduced toxicity. They emphasize the success of [lorcaserin] in targeting the [5HT2C serotonin receptor] for the treatment of [obesity] while minimizing off-target effects.

Unlocking New Possibilities: Reverse Engineering Revolutionizes Drug Development

This study showcases the potential of [reverse engineering] to revolutionize drug development, particularly in the challenging field of [CNS] therapies. The successful development of [lorcaserin] through this approach demonstrates the power of leveraging existing knowledge and innovative technologies to create more effective and safer medications.

A New Path to Better CNS Therapies: Reverse Engineering Offers Hope

Imagine a desert traveler stumbling upon a hidden oasis, providing a much-needed source of sustenance and renewal. Similarly, [reverse engineering] offers a promising new approach to developing effective and safe [CNS] therapies. This study sheds light on the transformative potential of this innovative strategy, offering hope for a brighter future for individuals suffering from [CNS] disorders.

Dr. Camel's Conclusion

This study showcases the promise of reverse engineering in drug development, particularly for central nervous system (CNS) therapies. It's a testament to the power of innovative approaches in addressing complex medical challenges. Just as a skilled desert traveler utilizes their knowledge of the terrain to navigate the vast landscape, researchers are employing reverse engineering to unlock new possibilities in the field of drug development. This study offers hope for a future where effective and safe CNS therapies are readily available to those who need them.

Date :
  1. Date Completed 2023-04-05
  2. Date Revised 2023-04-05
Further Info :

Pubmed ID

36928851

DOI: Digital Object Identifier

10.1007/978-3-031-21054-9_8

Related Literature

Article Analysis
・Side Effects of lorcaserin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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