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A critical review of methotrexate clinical interactions: role of transporters.

Author: AllahyariAbolghasem, ArastehOmid, AskariVahid Reza, Ataei AzimiSajad, HosseinjaniHesamoddin, JafariFatemeh

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Methotrexate (MTX) interactions with other medications can lead to elevated MTX levels and severe adverse effects. Drugs that can interact with MTX and increase its toxicity include indomethacin, ketoprofen, omeprazole, piperacillin/tazobactam, ciprofloxacin, cotrimoxazole, probenecid, and imatinib. This is mainly due to the role of transporters in drug metabolism. Patients with risk factors such as hypoalbuminemia, renal failure, third space fluid retention, and polypharmacy require careful monitoring for MTX toxicity.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Methotrexate (MTX) is an antifolate and immunosuppressive drug prescribed for various malignancies and immune diseases. However, delayed elimination of MTX associated with concomitant use of some medications can lead to severe and lifethreatening adverse effects. AREAS COVERED: This p...See full text at original site
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引用元：
https://doi.org/10.1080/17425255.2023.2193325

データ提供：米国国立医学図書館（NLM）

Methotrexate Interactions: Navigating the Desert of Drug Interactions

Methotrexate (MTX), a powerful drug used to treat various malignancies and immune diseases, can be a tricky camel to handle in the desert of drug interactions. This review, like a seasoned caravan leader, guides us through the complex world of MTX interactions, focusing on the role of transporters in determining MTX levels and related adverse effects. The review highlights the potential for delayed elimination of MTX when used concurrently with certain medications, leading to serious and potentially life-threatening consequences.

Methotrexate Toxicity: A Complex Desert of Interactions

The review emphasizes the intricate dance between MTX and other medications, revealing the complex interplay of transporters in influencing drug levels. This research, like a detailed map, provides valuable insights for healthcare professionals to navigate the potential risks of MTX interactions and ensure patient safety.

Implications for Health and Lifestyle

This review underscores the importance of consulting with a qualified healthcare professional to discuss any medications you are taking, especially if you are using MTX. It highlights the need for careful monitoring of MTX levels and potential drug interactions to prevent serious adverse effects. Understanding the complex interplay between drugs can help individuals make informed decisions about their healthcare.

Dr.Camel's Conclusion

This review offers a valuable guide to navigating the complex desert of methotrexate interactions, highlighting the importance of understanding the role of transporters in influencing drug levels and minimizing potential risks. By working closely with healthcare professionals and understanding the intricate interplay of medications, we can ensure the safe and effective use of methotrexate and other medications, ensuring a smooth journey through the desert of drug interactions.

Date :
  1. Date Completed 2023-04-10
  2. Date Revised 2023-04-10
Further Info :

Pubmed ID

36946211

DOI: Digital Object Identifier

10.1080/17425255.2023.2193325

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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