Side Effects of ketoprofen: A Synthesis of Findings from 25 Studies

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This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).

Original Abstract of the Article

Main Research Findings

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation. However, studies have shown that ketoprofen can have side effects, mainly affecting the gastrointestinal tract, kidneys, and liver.

For example, 2 research indicates that ketoprofen caused gastric bleeding and increased methane production in a rat model of colitis. 3 research found that ketoprofen may cause kidney damage and digestive issues in children.

Reasons for Side Effects

The main reason for ketoprofen’s side effects is its impact on the gastrointestinal tract. Ketoprofen inhibits the production of prostaglandins, which protect the stomach lining. This can make the stomach lining more susceptible to damage. Ketoprofen can also reduce blood flow to the kidneys, potentially leading to impaired kidney function.

Common Side Effects

Digestive System

Ketoprofen can cause various digestive side effects, as highlighted in studies 25 , 1 , 6 . The most common side effects include stomach pain, indigestion, nausea, vomiting, diarrhea, and constipation. It can also lead to more serious issues like gastric ulcers, duodenal ulcers, and peptic ulcers.

Kidney

Research in 3 suggests that ketoprofen may impair kidney function. This can manifest as symptoms like edema, reduced urine output, and blood in the urine. In severe cases, it may even lead to kidney failure.

Liver

Ketoprofen can place a burden on the liver. Liver function decline could lead to symptoms like jaundice, abdominal pain, and fatigue.

Measures to Counteract Side Effects

Digestive System

Taking ketoprofen with meals or in combination with antacids can help reduce gastrointestinal side effects. People with digestive diseases should consult a doctor before taking ketoprofen.

Kidney

Individuals with impaired kidney function or a history of kidney disease should consult a doctor before taking ketoprofen.

Liver

People with impaired liver function or a history of liver disease should consult a doctor before taking ketoprofen.

Comparison Across Studies

Commonalities Across Studies

Several studies consistently show that ketoprofen can have side effects on the digestive system, kidneys, and liver.

Differences Across Studies

The severity and incidence of ketoprofen side effects differ between studies. This can be attributed to various factors like the study participants, dosage, duration of treatment, and use of other medications.

Implications for Real-Life Applications

While ketoprofen is effective in relieving pain and inflammation, it is important to remember that it comes with side effect risks. When taking ketoprofen, strictly follow your doctor's instructions and the appropriate dosage. If you have concerns about side effects, reach out to your doctor.

Limitations of Current Research

There is still a lack of comprehensive research on the side effects of ketoprofen. Specifically, more studies are needed on long-term side effects and side effects in particular patient groups.

Future Directions for Research

To further understand the side effects of ketoprofen, long-term studies and studies focusing on specific patient populations are necessary. Developing new treatments and preventative measures to reduce side effects is also a promising area for future research.

Conclusion

Ketoprofen is an effective pain and inflammation reliever, but it carries side effect risks. Adhering to your doctor's instructions and proper dosage is vital when taking ketoprofen. If you have any concerns about side effects, consult your doctor. More research is needed to comprehensively understand the side effects of ketoprofen.

Keywords

Benefit Keywords

Risk Keywords

Literature analysis of 25 papers

Positive Content

Neutral Content

Negative Content

Article Type

Randomized Controlled Trial3

Meta-Analysis0

Systematic Review3

Review5

Journal Article25

Future prospects of ketoprofen in improving the safety of the gastric mucosa.

Author: KuczyńskaJoanna, Nieradko-IwanickaBarbara

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), is commonly used for its analgesic, anti-inflammatory, and antipyretic properties. However, its use is limited by various side effects. Researchers are actively working to develop modified versions of ketoprofen to improve its safety profile.

Language : English

Conjugation with Tris Decreases the Risk of Ketoprofen-Induced Mucosal Damage and Reduces Inflammation-Associated Methane Production in a Rat Model of Colitis.

Author: UgocsaiMelinda, BársonyAnett, VargaRéka Anna, GajdaÁmos, VidaNoémi, LajkóNorbert, RónaszékiBenedek, TóthGábor, BorosMihály, ÉrcesDániel, VargaGabriella

Colitis treatment

NSAID GI side effect reduction

Ket gastric bleeding

Ket methane output increase

This study designed a new compound, Ket-Tris, by conjugating ketoprofen (Ket) with Tris, aiming to reduce the gastrointestinal side effects of NSAID therapies. Ket-Tris demonstrated reduced inflammatory activation, methane emission, and colonic mucosal damage, without inducing gastric injury.

Language : English

Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents.

Author: EcclestonChristopher, CooperTess E, FisherEmma, AndersonBrian, WilkinsonNick Mr

Pain relief

Gastrointestinal issues

Renal impairment

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain management in children. They are licensed for use in Western countries, but not for infants under three months old. While they are generally effective for pain, fever, and inflammation, potential side effects include renal impairment, gastrointestinal issues, diarrhea, headache, nausea, constipation, rash, dizziness, and abdominal pain.

Language : English

The Anti-Inflammation and Anti-Nociception Effect of Ketoprofen in Rats Could Be Strengthened Through Co-Delivery of a H2S Donor, S-Propargyl-Cysteine.

Author: YuYue, YangQinyan, WangZhou, DingQian, LiMeng, FangYudong, HeQida, ZhuYi Zhun

GI toxicity mitigation

This study aimed to investigate the potential of S-propargyl-cysteine (SPRC), an endogenous H2S donor, to mitigate the gastrointestinal (GI) toxicity induced by ketoprofen (KETO), a traditional non-steroidal anti-inflammatory drug (NSAIDs).

Language : English

The effect of ketoprofen lysine salt on mucosa of rat stomach after ethyl alcohol intoxication.

Author: KuczyńskaJoanna, Nieradko-IwanickaBarbara

Gastric damage

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), can cause gastrointestinal side effects. Binge drinking, which is common in Europe, can increase the risk of gastric mucosa damage when NSAIDs are used the day after drinking.

Language : English

Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis.

Author: RedaRana Ihab, WenMing Ming, El-KamelAmal Hassan

No GIT side effects

Oral mucositis treatment

This study evaluated the efficacy of ketoprofen-loaded Eudragit L nanofibers (EL-NFs) for buccal administration to treat oral mucositis. The study found that EL-NFs were able to successfully deliver ketoprofen to the buccal mucosa, and that this method of delivery was effective in suppressing the inflammatory response associated with mucositis. This suggests that EL-NFs may be a safe and effective alternative to orally administered ketoprofen for the treatment of oral mucositis.

Language : English

Can NSAIDs and Acetaminophen Effectively Replace Opioid Treatment Options for Acute Pain?

Author: PergolizziJoseph V, MagnussonPeter, LeQuangJo Ann, BreveFrank, TaylorRobert, WollmuthCharles, VarrassiGiustino

Acute pain relief

NSAID risks

Opioid overdose

Nonopioid analgesics, such as acetaminophen and NSAIDs, are effective alternatives to opioids for acute pain. Combination therapy using a small amount of opioid with a nonopioid pain reliever can reduce opioid consumption.

Language : English

Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs.

Author: SatohH, KondoR, ShinodaT, IdakaS, IshigamiK, ShiotaniS

NSAID side effect reduction

Non-steroidal anti-inflammatory drugs (NSAIDs) can cause ulcers in the small intestine. This study investigated the effects of feeding condition and dietary fiber on the formation of NSAID-induced small intestinal ulcers in dogs.

Language : English

Medical management of acute non-specific low back pain: comparison of different medical treatments, one center's retrospective analysis.

Author: PernaA, RicciardiL, BaroneG, TamburrelliF C, ProiettiL, PolaE

Effective pain management

Higher compliance

Less side effects

This retrospective study compared the effectiveness of two treatments for non-specific acute low back pain (nsALBP). A combination of tramadol and dexketoprofen was associated with better pain control, fewer side effects, and higher patient satisfaction.

Language : English

10.

Users' Knowledge About Adverse Effects of Non-steroidal Anti-inflammatory Drugs in Tirana, Albania.

Author: RoshiDajana, ToçiErvin, BurazeriGenc, Schröder-BäckPeter, MalajLedjan, BrandHelmut

Limited knowledge of NSAID side effects

A survey of adult NSAID users in Albania revealed limited knowledge about NSAID side effects and drug interactions.

Language : English

11.

Future prospects of ketoprofen in improving the safety of the gastric mucosa.

Author: KuczyńskaJoanna, Nieradko-IwanickaBarbara

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), is commonly used for its analgesic, anti-inflammatory, and antipyretic properties. However, its use is limited by various side effects. Researchers are actively working to develop modified versions of ketoprofen to improve its safety profile.

Language : English

12.

Pain Management in Children: NSAID Use in the Perioperative and Emergency Department Settings.

Author: CooneyMaureen F

Opioid reduction

Pain relief

Adverse events

This review of 27 studies found that NSAIDs reduced the need for opioids in 10 out of 13 studies and did not worsen pain relief. In 24 out of 27 studies, NSAIDs provided better or similar pain scores compared to opioids. Adverse effects were reported in 26 studies. Three studies showed that NSAIDs had fewer adverse effects than opioids, 21 studies showed similar adverse effect rates, and 2 studies showed that NSAIDs had more frequent adverse effects.

Language : English

13.

Improved enantioselectivity of thermostable esterase from Archaeoglobus fulgidus toward (S)-ketoprofen ethyl ester by directed evolution and characterization of mutant esterases.

Author: KimJinyeong, KimSeungbum, YoonSangyoung, HongEunsoo, RyuYeonwoo

High thermostability

Improved enantioselectivity

Thermostable esterases are valuable in biotechnology due to their heat and solvent resistance. This study engineered mutants of Est-AF, an esterase from Archaeoglobus fulgidus, to improve enantioselectivity while retaining high thermostability. Two mutants, V138G and V138G/L200R, showed significantly improved enantioselectivity without compromising thermostability.

Language : English

14.

Novel pH-sensitive interpenetrated network polyspheres of polyacrylamide-g-locust bean gum and sodium alginate for intestinal targeting of ketoprofen: In vitro and in vivo evaluation.

Author: BoppanaRashmi, Yadaorao RautSushil, Krishna MohanG, SaBiswanath, MutalikSrinivas, ReddyKakarla Raghava, DasKusal K, BiradarMallanagouda S, KulkarniRaghavendra V

Reduced side effects

Targeted drug delivery

Novel pH-sensitive interpenetrated network (IPN) polyspheres, composed of polyacrylamide-g-locust bean gum (PAAm-g-LBG) and sodium alginate (SA), were developed for intestinal-targeted delivery of ketoprofen. The IPN polyspheres exhibited pH-dependent swelling and de-swelling, enabling controlled drug release in the small intestine. In vivo studies in rats showed successful intestinal targeting, resulting in reduced ketoprofen-related side effects like gastric ulcers.

Language : English

15.

Synthesis and biological evaluation of RGD conjugated with Ketoprofen/Naproxen and radiolabeled with [99mTc] via N4(GGAG) for αVβ3 integrin-targeted drug delivery.

Author: MohammadiReza, ShokriBahareh, ShamshirianDanial, ZarghiAfshin, ShahhosseiniSoraya

Cancer treatment

Targeted drug delivery

Targeted delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) into cancer cells by using RGD as a carrier may gain increased clinical interest.

Language : English

16.

Preparation and in vitro evaluation of hot-melt extruded pectin-based pellets containing ketoprofen for colon targeting.

Author: NaralaSagar, NyavanandiDinesh, MandatiPreethi, YoussefAhmed Adel Ali, AlzahraniAbdullah, KolimiPraveen, ZhangFeng, RepkaMichael

Colon drug delivery

This study describes the development of high drug-load pellets for colon targeting using a combined hot-melt extrusion (HME) and die-surface cutting pelletizer process. Ketoprofen (KTP), a drug known for its severe gastrointestinal side effects, was used as a model drug. The study demonstrates the feasibility of this continuous process for developing colon-targeted drug delivery systems.

Language : English

17.

Ketoprofen versus Diclofenac sodium in the treatment of renal colic.

Author: JebaliChawki, BoukadidaLotfi, ChabaaneWael, Haj AliAchref, OusgiAli, BoukefRiadh

Renal colic treatment

This study compared the efficacy and safety of two intramuscularly administered nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with renal colic.

Language : English

18.

Efficacy and Clinical Value of Commonly Used Ingredients in Pain Management Compounds: A LITERATURE REVIEW.

Author: BeshaySarah M, RiveraGerard, BalthasarJan, FloreaNaomi

Improved pain management

Side effects

This review discusses the clinical and therapeutic value of lidocaine, tetracaine, ketoprofen, ketamine, and gabapentin, commonly used ingredients in pain management compounds.

Language : English

19.

Lipase Assisted (S)-Ketoprofen Resolution from Commercially Available Racemic Mixture.

Author: Estrada-ValenzuelaDaniela, Ramos-SánchezVíctor H, Zaragoza-GalánGerardo, Espinoza-HicksJose C, BugarinAlejandro, Chávez-FloresDavid

Enantiomer resolution

Increased potency

Reduced side effects

This study investigated the use of Candida rugosa lipase to kinetically resolve racemic ketoprofen. The study achieved high enantioselectivity (E=185) with an esterification conversion of 47% and enantiomeric excess of 99%. The undesired (R)-enantiomer was recycled, demonstrating the benefit and efficiency of this environmentally friendly protocol.

Language : English

20.

The Dose-Dependent Effects of Ketoprofen on Dynamic Pain after Open Heart Surgery.

Author: EljeziVedat, BibouletClaire, BobyHenri, SchoefflerPierre, PereiraBruno, DualeChristian

Reduced pain

Intravenous ketoprofen at a standard dose of 0.5 mg/kg every 6 hours effectively reduced dynamic and static postoperative pain after open heart surgery, without any negative effects on tolerance outcomes. Lower doses of ketoprofen were not effective in reducing pain.

Language : English

21.

[Application of synthetic and semisynthetic polymers (Kollidon K30 and hydroxypropylmethylcellulose) as carriers of ketoprofen in solid oral prolonged-release dosage forms].

Author: LinkaWojciech, KotMateusz, KołodziejczykMichał

Drug effectiveness

Reduced side effects

This study investigated the suitability of polymers (Kollidon K30 and hydroxypropyl methylcellulose) and calcium hydrogen phosphate dihydrate as fillers for the construction of matrices for solid oral dosage forms containing ketoprofen. The study found that formulations containing hydroxypropyl methylcellulose and calcium hydrogen phosphate dihydrate resulted in prolonged release of ketoprofen, while Kollidon K30 accelerated release. This suggests that hydroxypropyl methylcellulose and calcium hydrogen phosphate dihydrate may be useful for developing prolonged release formulations of ketoprofen.

Language : Polish

22.

Tapentadol vs oxycodone/naloxone in the management of pain after total hip arthroplasty in the fast track setting: an observational study.

Author: D'AmatoTiziana, MartorelliFederica, FenocchioGiorgia, SimiliVincenzo, KonElizaveta, Di MatteoBerardo, ScardinoMarco

Pain management

Tapentadol or oxycodone/naloxone in combination with ketoprofene are effective in managing postoperative pain in patients undergoing total hip replacement surgery.

Language : English

23.

[The effectiveness of preemptive analgesic techniques on postoperative analgesia in patients undergoing open septorhinoplasty].

Author: Keskioğluİlknur, Aktay İnalMeltem, ÖzlüOnur

Postoperative analgesia

Reduced pain

None reported

This study compared the effects of preincisional intravenous (IV) dexketoprofen trometamol and acetaminophen on postoperative pain, analgesic requirement, and patient satisfaction in patients undergoing elective septorhinoplasty. Both preemptive IV dexketoprofen trometamol and acetaminophen were effective for postoperative analgesia; however, preemptive dexketoprofen trometamol was more effective than acetaminophen for postoperative analgesia.

Language : Turkish

24.

A critical review of methotrexate clinical interactions: role of transporters.

Author: JafariFatemeh, ArastehOmid, HosseinjaniHesamoddin, AllahyariAbolghasem, Ataei AzimiSajad, AskariVahid Reza

Methotrexate toxicity

Methotrexate (MTX) interactions with other medications can lead to elevated MTX levels and severe adverse effects. Drugs that can interact with MTX and increase its toxicity include indomethacin, ketoprofen, omeprazole, piperacillin/tazobactam, ciprofloxacin, cotrimoxazole, probenecid, and imatinib. This is mainly due to the role of transporters in drug metabolism. Patients with risk factors such as hypoalbuminemia, renal failure, third space fluid retention, and polypharmacy require careful monitoring for MTX toxicity.

Language : English

25.

Chemical Modifications of Ketoprofen (NSAID) in Search of Better Lead Compounds: A Review of Literature From 2004-2016.

Author: ChawlaGita, RanjanChanda, KumarJagdish, SiddiquiAnees A

This review summarizes the chemical modifications of ketoprofen, a potent anti-inflammatory drug, that have been explored to improve its safety and efficacy. The modifications aim to reduce gastric side effects and explore new therapeutic applications.

Language : English

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