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A phase I clinical trial of sonodynamic therapy combined with temozolomide in the treatment of recurrent glioblastoma.

Author: CuiHaiyang, DangQianqian, HuangfuLinkuan, LiPeihong, LiYuxin, ShiShuling, WuJingjing, YangDaoke, YangJunping, ZhaBoya, ZhengYingjuan

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Recurrent glioblastoma (rGBM) has a poor prognosis. This pilot study investigated the safety, tolerability, and efficacy of sonodynamic therapy (SDT) for treating rGBM.
Paper Details　
Original Abstract of the Article :
The prognosis of recurrent glioblastoma (rGBM) is poor, and there is currently no effective treatment strategy. Sonodynamic therapy (SDT) is a new method for cancer treatment that uses a combination of low-frequency ultrasound and sonosensitisers to produce antitumor effects, which have shown good t...See full text at original site
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引用元：
https://doi.org/10.1007/s11060-023-04292-9

データ提供：米国国立医学図書館（NLM）

Sonodynamic Therapy: A New Hope for Glioblastoma?

This research explores the potential of [sonodynamic therapy (SDT)] as a new treatment approach for [recurrent glioblastoma (rGBM)], a particularly aggressive form of brain cancer. The study uses a [phase I clinical trial] design to evaluate the [safety, tolerability, and efficacy] of SDT in treating rGBM. The study's findings suggest that [SDT appears to be a promising new treatment option for rGBM], showing early signs of efficacy and safety in a small group of patients.

Sonodynamic Therapy: A Potential Oasis in the Desert of Glioblastoma Treatment

The study's findings, while preliminary, offer a glimmer of hope in the challenging landscape of glioblastoma treatment. SDT presents a novel approach that warrants further investigation. It's like discovering a hidden spring in a barren desert—a source of potential healing.

Navigating the Uncertainties of Glioblastoma Treatment: A Guide for the Desert Traveler

As we journey through the desert of glioblastoma research, finding effective treatments remains a top priority. While this study provides an encouraging glimpse into the potential of SDT, it's crucial to remember that [further research is needed] to confirm its effectiveness and safety. Consult with healthcare professionals for personalized treatment options.

Dr.Camel's Conclusion

The desert of glioblastoma research is vast and unforgiving, but the discovery of SDT offers a potential oasis of hope. This new therapy shows promise, but it's important to stay vigilant and keep exploring the possibilities. Just as a camel adapts to the harsh desert environment, we must continue to adapt and innovate in the fight against this devastating disease.
Date :
  1. Date Completed 2023-05-10
  2. Date Revised 2023-05-10
Further Info :

Pubmed ID

36988745

DOI: Digital Object Identifier

10.1007/s11060-023-04292-9

Related Literature

Article Analysis
・Effects of temozolomide injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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