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Repurposing <i>Astragalus</i> Polysaccharide PG2 for Inhibiting ACE2 and SARS-CoV-2 Spike Syncytial Formation and Anti-Inflammatory Effects.

Author: ChangChih-Hung, ChuLi-Wei, DoanLy Hien, HuangChi-Ying F, LaiJin-Mei, LeeChia-Yin, LeeI-Lin, LiaoHsiu-Jung, LiuHui-Kang, NguyenAnh Thuc, PingYueh-Hsin, TsaoShih-Ming, WangTeng-Hsu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the potential of *Astragalus* polysaccharide (PG2) as a novel anti-coronavirus therapeutic. The study found that PG2 effectively reversed COVID-19 signature genes and prevented the fusion of cells expressing viral spike (S) protein and ACE2. PG2 also enhanced the expression levels of miRNAs that could reduce viral replication and cytokine storm. Additionally, PG2 regulated macrophage activation by promoting the polarization of macrophages into an anti-inflammatory phenotype. These findings suggest that PG2 has the potential to prevent and treat COVID-19 by targeting multiple aspects of the disease process.
Paper Details　
Original Abstract of the Article :
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious threat to global public health. In an effort to develop novel anti-coronavirus therapeutics and achieve prophylactics, we used gene set enrichment analysis (GSEA...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054482/

データ提供：米国国立医学図書館（NLM）

Repurposing Astragalus Polysaccharide PG2: A New Oasis in the Desert of COVID-19 Treatment

The COVID-19 pandemic has posed unprecedented challenges to global health. This research explores the potential of Astragalus polysaccharide PG2, a natural compound derived from the Astragalus membranaceus plant, as a repurposed drug for the treatment of COVID-19. The study found that PG2 could inhibit the binding of SARS-CoV-2 spike protein to ACE2 receptors, potentially preventing viral entry into cells. The study also suggests that PG2 could have anti-inflammatory effects, potentially mitigating the cytokine storm associated with severe COVID-19. The research holds promise for the development of new therapies for COVID-19, leveraging the potential of existing natural compounds.

Finding Hope in the Desert of COVID-19: The Promise of Repurposed Drugs

COVID-19, like a desert sandstorm, has swept across the world, causing widespread disruption and suffering. This research explores the potential of repurposing an existing natural compound, Astragalus polysaccharide PG2, as a treatment for this devastating disease. The study's findings offer a glimmer of hope, suggesting that this compound could potentially inhibit viral entry into cells and reduce the severity of COVID-19 symptoms.

The Desert of COVID-19: A Search for New Oasis

The COVID-19 pandemic has brought about a race to find new treatments and therapies. This research explores a promising path, leveraging the potential of repurposing existing natural compounds. The study's findings suggest that Astragalus polysaccharide PG2 could offer a new oasis of treatment, potentially reducing viral entry into cells and mitigating the severity of COVID-19 symptoms.

Dr.Camel's Conclusion

This study offers a ray of hope in the desert of COVID-19 treatment. The findings suggest that Astragalus polysaccharide PG2, a natural compound with a long history of medicinal use, could be repurposed as a therapeutic agent for COVID-19. The study highlights the importance of exploring existing natural compounds for potential therapeutic applications, potentially leading to new treatments for this devastating disease.
Date :
  1. Date Completed 2023-04-06
  2. Date Revised 2023-04-14
Further Info :

Pubmed ID

36992350

DOI: Digital Object Identifier

PMC10054482

Related Literature

Article Analysis
・Effective treatment of astragalus
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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