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Effects of changing the timing of warfarin administration in combination with fluconazole on prolongation of the PT-INR: a case report.
Author: AkamatsuHayato, HarasawaHitomi, HashizumeJunya, KodamaYukinobu, MatsumaruIchiro, MiuraTakashi, NakagawaHiroo, OhyamaKaname
Original Abstract of the Article :
Fluconazole (FLCZ) inhibits cytochrome P450 (CYP) 2C9, 2C19, and 3A4 and has a drug-drug interaction that potentiates the effects of warfarin and prolong the prothrombin time-international normalized ratio (PT-INR). Although a drug-drug interaction have been reported between FLCZ and warfarin, the e...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067283/
データ提供:米国国立医学図書館(NLM)
Warfarin and Fluconazole: A Desert of Drug Interactions
The world of drug interactions can feel like a vast and confusing desert, filled with hidden dangers and unpredictable reactions. This case report investigates the effects of fluconazole, an antifungal medication, on the anticoagulant properties of warfarin, a drug commonly used to prevent blood clots. The report focuses on the potential for drug interactions between these two medications, specifically exploring how the timing of their administration can influence the prolongation of the prothrombin time-international normalized ratio (PT-INR), a key measure of blood clotting time.
Timing Matters: A Case of Warfarin-Fluconazole Interaction
The case report highlights the potential for a significant drug interaction between fluconazole and warfarin, underscoring the importance of careful monitoring and management of patients receiving both medications. The report emphasizes the need for close clinical observation and regular monitoring of PT-INR levels to ensure patient safety and prevent potential complications. This case underscores the importance of understanding the complexities of drug interactions and the critical role of pharmacists and physicians in ensuring patient safety.
Navigating the Desert of Drug Interactions: Safety First
This research highlights the crucial importance of understanding and managing drug interactions. The case report underscores the need for close monitoring and communication between healthcare providers to ensure patient safety when administering medications with the potential for interactions. By understanding the potential consequences of drug interactions, we can minimize risks and ensure the safe and effective use of medications for those in need.
Dr.Camel's Conclusion
The case report of warfarin and fluconazole interaction is like navigating a treacherous desert of drug interactions, where unexpected encounters can lead to dangerous consequences. The study emphasizes the importance of carefully considering the timing of medication administration and monitoring PT-INR levels to prevent potential complications. This research serves as a reminder that patient safety is paramount, and a thorough understanding of drug interactions is essential for ensuring the safe and effective use of medications.
Date :
- Date Completed n.d.
- Date Revised 2023-04-04
Further Info :
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