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Effectiveness of Conditioned Open-label Placebo With Methadone in Treatment of Opioid Use Disorder: A Randomized Clinical Trial.

Author: BelcherAnnabelle M, BillingAmy S, ColeThomas O, CollocaLuana, EpsteinDavid H, GreenblattAaron D, HoagStephen W, KaptchukTed J, MagderLawrence, MasseyEbonie, RotrosenJohn, WagnerMichael, WeintraubEric, WickwireEmerson M, WishEric D, WootenWilliam

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Methadone is a highly effective treatment for opioid addiction, but challenges with dosing and people stopping treatment early highlight the need for additional support. This study explores the potential of using the placebo effect, which involves the power of belief, as a low-risk intervention to improve treatment outcomes for people on methadone.
Paper Details　
Original Abstract of the Article :
Methadone treatment is the most effective evidence-based treatment for opioid use disorder (OUD), but challenges related to dosing and premature treatment dropout argue for adjunct interventions to improve outcomes. One potential behavioral intervention with low risk involves harnessing placebo effe...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099063/

データ提供：米国国立医学図書館（NLM）

Harnessing the Power of Placebo: A New Path Through the Desert of Opioid Use Disorder

Opioid use disorder (OUD) is a challenging condition, a vast desert of addiction and dependence. Methadone treatment is considered the gold standard, but many patients struggle with dosing and premature treatment dropout. This study explores the potential of a unique behavioral intervention, conditioned open-label placebo, as an adjunct to methadone treatment. The researchers believe that harnessing the power of placebo effects could improve treatment outcomes and enhance patient engagement.

The Placebo Effect: A Beacon in the Desert of Addiction

The study's key finding is that conditioned open-label placebo, a technique that involves patients' belief in the effectiveness of a placebo, can enhance the efficacy of methadone treatment for OUD. This discovery is a valuable step toward finding more effective and engaging treatment strategies for this challenging condition. The authors emphasize the importance of exploring the potential of behavioral interventions to improve outcomes for patients with OUD, highlighting the need for a multi-pronged approach to treatment.

Navigating the Desert of Addiction: Finding Hope Through Placebo Effects

This research offers a glimmer of hope in the challenging landscape of OUD treatment. The study's findings highlight the potential of harnessing placebo effects to enhance the effectiveness of methadone therapy, a promising avenue for improving patient outcomes. By understanding the power of the placebo effect, we can develop more effective and engaging treatment strategies for OUD, providing a beacon of hope for those struggling with addiction.

Dr.Camel's Conclusion

The study of conditioned open-label placebo in OUD treatment is like discovering a hidden oasis in the desert of addiction. It reveals the power of the placebo effect, a powerful tool for improving treatment outcomes and offering hope to those struggling with opioid dependence. This research is a valuable step towards finding more effective and compassionate treatment strategies for OUD, a crucial endeavor for addressing this public health crisis.

Date :
  1. Date Completed 2023-04-14
  2. Date Revised 2023-04-25
Further Info :

Pubmed ID

37043203

DOI: Digital Object Identifier

PMC10099063

Related Literature

Article Analysis
・Effective treatment of opioid use
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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