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The orexin story and orexin receptor antagonists for the treatment of insomnia.

Author: DingemanseJasper, MuehlanClemens, RochCatherine, VaillantCedric

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Insomnia is a common sleep disorder, and orexin receptor antagonists are a new class of medications for its treatment. These medications block the orexin pathway, which promotes arousal, and have been shown to be effective in improving sleep quality. While they appear to have a favorable safety profile, further research is needed to understand their long-term effects and potential interactions with other medications.
Paper Details　
Original Abstract of the Article :
Insomnia is present in up to one third of the adult population worldwide, and it can present independently or with other medical conditions such as mental, metabolic, or cardiovascular diseases, which highlights the importance of treating this multifaceted disorder. Insomnia is associated with an ab...See full text at original site
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引用元：
https://doi.org/10.1111/jsr.13902

データ提供：米国国立医学図書館（NLM）

Orexin Receptor Antagonists for Insomnia: A Desert of Restlessness

Insomnia, a sleep disorder characterized by difficulty falling asleep or staying asleep, is a common condition that can disrupt the tranquility of our lives. This research explores the role of orexin, a neurotransmitter involved in wakefulness, in the development of insomnia. The study examines the potential of orexin receptor antagonists as a new therapeutic approach for treating insomnia, aiming to understand how blocking orexin signaling could improve sleep quality and reduce insomnia symptoms.

Orexin Receptor Antagonists: A New Oasis in the Desert of Insomnia

The study highlights the potential of orexin receptor antagonists to offer a novel approach for treating insomnia. These drugs work by blocking the orexin pathway, which is involved in promoting wakefulness, leading to improved sleep quality and reduced insomnia symptoms. The study suggests that orexin receptor antagonists may be a viable option for long-term treatment of insomnia, as they do not appear to induce dependence or tolerance, unlike some traditional sleep medications.

Navigating the Desert of Insomnia: A New Path to Restful Sleep

This research opens a new path in the desert of insomnia, offering a promising therapeutic approach with orexin receptor antagonists. The study emphasizes the importance of exploring innovative treatments for insomnia, focusing on alternative mechanisms of action that can address the underlying causes of sleep disturbances.

Dr. Camel's Conclusion

The desert of insomnia can be a challenging and exhausting landscape, leaving many yearning for restful sleep. This research provides a glimmer of hope, highlighting the potential of orexin receptor antagonists to offer a new oasis in the desert of insomnia. By exploring new pathways and innovative therapies, we can continue to navigate the desert of sleep disturbances, seeking solutions to improve sleep quality and promote a more restful and fulfilling life.

Date :
  1. Date Completed 2023-11-30
  2. Date Revised 2023-11-30
Further Info :

Pubmed ID

37086045

DOI: Digital Object Identifier

10.1111/jsr.13902

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Languages

English

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