Effects of lemborexant: A Synthesis of Findings from 15 Studies

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Original Abstract of the Article

Main Research Findings

Lemborexant, a novel dual orexin receptor antagonist, has been shown to be effective in treating insomnia in several studies. Lemborexant was more effective than placebo in improving sleep latency, wake time after sleep onset, and sleep efficiency. 15 Lemborexant was also shown to be superior to other sleep medications in terms of sleep quality and next-day alertness. 15 Additionally, lemborexant has a low risk of dependence and tolerance, making it a viable option for long-term treatment. 10

However, lemborexant can cause side effects such as drowsiness, dizziness, headache, and digestive problems. 15 Lemborexant may also interact with other medications, such as clozapine. 5 It is not recommended for pregnant or breastfeeding women. 7

Benefits and Risks

Benefit Summary

Lemborexant is a new drug that can be effective for treating insomnia. It may help improve sleep quality and next-day alertness. Additionally, lemborexant has a low risk of dependence and tolerance, making it suitable for long-term use.

Risk Summary

Lemborexant can cause side effects such as drowsiness, dizziness, headache, and digestive problems. It may also interact with other medications. Pregnant or breastfeeding women should avoid using lemborexant.

Comparison Across Studies

Commonalities

Several studies have shown that lemborexant is more effective than placebo in improving sleep latency, wake time after sleep onset, and sleep efficiency. It has also been suggested that lemborexant may be superior to other sleep medications in terms of sleep quality and next-day alertness.

Differences

The effects and side effects of lemborexant may vary depending on the study. This could be explained by differences in study design, participant characteristics, and other factors.

Consistency and Discrepancies of Findings

Multiple studies have shown that lemborexant is an effective treatment for insomnia. However, there are some inconsistencies in the findings regarding the magnitude of its effects and side effects. These discrepancies could be explained by differences in study design, participant characteristics, and other factors. Further research is needed to clarify these inconsistencies.

Implications for Real-World Application

Lemborexant is a potentially effective treatment for insomnia, but it is important to be aware of its potential side effects. When using lemborexant, it is crucial to follow the doctor's instructions and take the medication correctly. Lemborexant may interact with other medications, so it is important to inform your doctor about any other medications you are taking.

Limitations of Current Research

There is still limited research on lemborexant, particularly regarding its long-term safety and efficacy. More research is needed in these areas.

Future Research Directions

Further research is needed to investigate the long-term safety and efficacy of lemborexant. More research is also needed on the potential interactions between lemborexant and other medications. Long-term studies on the risk of dependence and tolerance with lemborexant are also needed.

Conclusion

Lemborexant shows promise as a new treatment for insomnia. However, it is important to consider its potential side effects. It is crucial to follow your doctor's instructions and take the medication correctly. Further research is needed to fully understand the benefits and risks of lemborexant.

Literature analysis of 15 papers
Positive Content
13
Neutral Content
1
Negative Content
1
Article Type
4
2
2
2
14
1.

Acute Cognitive Effects of the Dual Orexin Receptor Antagonist Lemborexant Compared With Suvorexant and Zolpidem in Recreational Sedative Users.

Author: LandryIshani, HallNancy, AlurJagadeesh, FilippovGleb, ReydermanLarisa, SetnikBeatrice, HenningfieldJack, MolineMargaret

This study investigates the effects of therapeutic and supratherapeutic doses of lemborexant, a new orexin antagonist, on cognition and psychomotor performance in healthy, non-dependent recreational sedative users, comparing it to placebo and supratherapeutic doses of zolpidem and suvorexant.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Efficacy and safety of lemborexant in subjects previously treated with placebo for 6 months in a randomized phase 3 study.

Author: YardleyJane, InoueYuichi, PinnerKate, PerdomoCarlos, KubotaNaoki, PerlisMichael L, MolineMargaret

Insomnia treatment

Lemborexant 5 mg and 10 mg showed sustained clinical gains in sleep outcomes even after extended placebo treatment. The safety profile was similar between treatment periods and groups.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Lemborexant levels in breast milk after single doses in healthy, lactating women.

Author: RawalSumit, BrimhallDarin, AluriJagadeesh, ChengJocelyn Y, HallNancy, MolineMargaret

Insomnia treatment
Breast milk

Lemborexant was found in trace quantities in human breast milk. The drug was well tolerated by healthy lactating women.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Lemborexant Attenuates Regurgitation without Worsening Objective Parameters on Reflux Monitoring in Patients with Gastroesophageal Reflux Disease and Insomnia: A Single-Arm Proof-of-Concept Study.

Author: HoshikawaYoshimasa, MommaEri, KawamiNoriyuki, IwakiriKatsuhiko

GERD amelioration

This study investigated the effects of lemborexant, a new hypnotic, on gastroesophageal reflux disease (GERD). Lemborexant has shown greater efficacy and fewer adverse effects than zolpidem, another hypnotic. The study suggests that lemborexant may be a beneficial treatment option for GERD by improving sleep quality and reducing esophageal hypersensitivity.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Evaluation of the delirium preventive effect of dual orexin receptor antagonist (DORA) in critically ill adult patients requiring ventilation with tracheal intubation at an advanced emergency center: A single-center, retrospective, observational study.

Author: MatsuokaAyaka, SogawaRintaro, Murakawa-HirachiToru, MizoguchiYoshito, MonjiAkira, ShimanoeChisato, ShinadaKota, KoamiHiroyuki, SakamotoYuichiro

Prevention of ICU delirium

This study retrospectively evaluated the efficacy of dual orexin receptor antagonists (DORAs) in preventing delirium in critically ill adult patients requiring ventilatory management.

Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

The orexin story and orexin receptor antagonists for the treatment of insomnia.

Author: MuehlanClemens, RochCatherine, VaillantCedric, DingemanseJasper

Insomnia treatment
Long-term treatment

Insomnia is a common sleep disorder, and orexin receptor antagonists are a new class of medications for its treatment. These medications block the orexin pathway, which promotes arousal, and have been shown to be effective in improving sleep quality. While they appear to have a favorable safety profile, further research is needed to understand their long-term effects and potential interactions with other medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Efficacy and safety of lemborexant as an alternative drug for patients with insomnia taking gamma-aminobutyric acid-benzodiazepine receptor agonists or suvorexant.

Author: OkinoKazumaro, SuzukiHirohisa, TomiokaHiroi, SanadaKenji, KawaiKeita, IwanamiAkira, InamotoAtsuko

Insomnia treatment
Adverse events

While GABA-BZ receptor agonists are used to treat insomnia, long-term or high-dosage use can lead to adverse events. Suvorexant, an orexin receptor antagonist, effectively prevents nocturnal awakening in 70%-75% of patients with insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

The Comparative Effectiveness and Safety of Insomnia Drugs: A Systematic Review and Network Meta-Analysis of 153 Randomized Trials.

Author: PanBei, GeLong, LaiHonghao, HouLiangying, TianChen, WangQi, YangKelu, LuYao, ZhuHongfei, LiMengting, WangDeren, LiXiuxia, ZhangYuqing, GaoYa, LiuMing, DingGuowu, TianJinhui, YangKehu

Insomnia management

This study aimed to determine the relative effectiveness, safety, and tolerability of drugs for insomnia. The study found that there is a lack of evidence comparing the relative effectiveness, safety, and certainty of evidence among drug classes and individual drugs for insomnia.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Effects of atomoxetine plus a hypnotic on obstructive sleep apnea severity in patients with a moderately collapsible pharyngeal airway.

Author: CorserBruce, EvesErica, Warren-McCormickJennifer, RucoskyGregg

OSA treatment
sleep quality improvement
OSA severity reduction
atomoxtine/oxybutynin tolerance

This study investigates the combination of atomoxetine and hypnotics (trazodone or lemborexant) in patients with obstructive sleep apnea (OSA). The combination improved OSA severity but also reduced the arousal threshold, potentially leading to poor tolerability in patients with disturbed sleep.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Efficacy and tolerability of pharmacological treatments for insomnia in adults: A systematic review and network meta-analysis.

Author: YueJing-Li, ChangXiang-Wen, ZhengJun-Wei, ShiLe, XiangYa-Jie, QueJian-Yu, YuanKai, DengJia-Hui, TengTeng, LiYang-Yang, SunWei, SunHong-Qiang, VitielloMichael V, TangXiang-Dong, ZhouXin-Yu, BaoYan-Ping, ShiJie, LuLin

Improved sleep quality
Reduced pain intensity
Long-term adverse effects

Insomnia is a common problem, and there are many medications available to treat it. This review of 69 studies found that orexin receptor antagonists (ORAs) were more effective than other drugs for insomnia, with good tolerability, while Z-drugs were also effective but had a higher risk of side effects.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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