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Endometrial Angiogenesis of Abnormal Uterine Bleeding and Infertility in Patients with Uterine Fibroids-A Systematic Review.

Author: DonEmma E, GriffioenArjan W, HehenkampWouter J K, HuirneJudith A F, MiddelkoopMei-An, MijatovicVelja

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Uterine fibroids are common, non-cancerous growths in the uterus that can cause heavy bleeding and infertility. This study found that fibroids are linked to abnormal blood vessel growth in the uterine lining (endometrium). Treatments like hormone therapy seem to reduce this abnormal blood vessel growth. The study also suggests that different blood vessel pathways may be involved in fibroids that cause infertility. These findings may lead to new treatments targeting blood vessel growth to address fibroid-related symptoms.
Paper Details　
Original Abstract of the Article :
Uterine fibroids are the most common benign tumors in women, with abnormal uterine bleeding (AUB) as the main reported symptom. Additionally, an association between fibroids and infertility has been established, especially if the fibroid protrudes in the uterine cavity. Hormonal therapy is associate...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138959/

データ提供：米国国立医学図書館（NLM）

Unveiling the Role of Endometrial Angiogenesis in Fibroid-Related Symptoms

Uterine fibroids, benign tumors in the uterus, are a common condition that can cause a range of symptoms, including abnormal uterine bleeding (AUB) and infertility. This systematic review explores the role of endometrial angiogenesis, the formation of new blood vessels in the endometrium, in fibroid-related symptoms. The review investigates the potential mechanisms by which altered angiogenesis contributes to AUB and infertility in women with fibroids.

Delving into the Complexities of Fibroid-Related Symptoms

The review found that endometrial angiogenesis is often altered in women with fibroids, suggesting a potential link to the development of AUB and infertility. The study suggests that aberrant angiogenesis might contribute to the development of immature and fragile vessels, potentially explaining the bleeding and fertility issues. It's like navigating a desert, where the presence of an oasis can be a sign of a hidden spring, but also a potential for unexpected challenges.

The Potential for Targeted Therapies in Fibroid Management

The review's findings highlight the potential for targeted therapies that address the underlying mechanisms of endometrial angiogenesis in fibroids. This research opens up new avenues for developing treatments that could potentially alleviate AUB and improve fertility in women with fibroids. Just as a desert traveler needs to understand the landscape to navigate effectively, healthcare providers need to understand the underlying mechanisms of disease to develop targeted therapies.

Dr. Camel's Conclusion

This systematic review sheds light on the role of endometrial angiogenesis in fibroid-related symptoms. The review's findings suggest that aberrant angiogenesis may contribute to the development of AUB and infertility in women with fibroids. This research opens up new possibilities for developing targeted therapies that could potentially improve patient outcomes and quality of life. It's a reminder that the desert of medicine is vast and complex, requiring constant exploration and innovation to uncover new solutions for treating challenging conditions.

Date :
  1. Date Completed 2023-05-01
  2. Date Revised 2023-05-01
Further Info :

Pubmed ID

37108180

DOI: Digital Object Identifier

PMC10138959

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・Effective treatment of uterine fibroids
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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