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Verproside, the Most Active Ingredient in YPL-001 Isolated from <i>Pseudolysimachion rotundum</i> var. <i>subintegrum</i>, Decreases Inflammatory Response by Inhibiting PKC&#948; Activation in Human Lung Epithelial Cells.

Author: HongSung-Tae, KimDoo-Young, KimMun-Ock, KimTae-Don, LeeJae-Won, LeeJinhyuk, LeeSu Ui, OhEun Sol, OhSei-Ryang, ParkJi-Yoon, RoHyunju, RyuHyung Won, SongYu Na

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study identified verproside as the most effective iridoid in YPL-001 for reducing airway inflammation in NCI-H292 cells. Verproside effectively reduces lung inflammation in a COPD-mouse model by suppressing PKCδ activation and mucus overproduction, suggesting its potential as a candidate drug for treating inflammatory lung diseases.
Paper Details　
Original Abstract of the Article :
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease which causes breathing problems. YPL-001, consisting of six iridoids, has potent inhibitory efficacy against COPD. Although YPL-001 has completed clinical trial phase 2a as a natural drug for COPD treatment, the most...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138391/

データ提供：米国国立医学図書館（NLM）

Verproside: A Desert Oasis for COPD

This research explores the challenging terrain of chronic obstructive pulmonary disease (COPD), a chronic lung disease that affects millions worldwide. The study investigates the therapeutic potential of verproside, a compound found in the plant Pseudolysimachion rotundum var. subintegrum, in reducing airway inflammation associated with COPD. The findings reveal that verproside effectively inhibits inflammation by targeting a specific signaling pathway, offering a potential new treatment for COPD.

A Desert Bloom: Taming Inflammation in COPD

The study found that verproside effectively reduced airway inflammation in both cell culture and animal models of COPD, by inhibiting the activation of a key signaling molecule called PKCδ. This is like discovering a rare desert flower that produces a potent anti-inflammatory compound, offering a natural remedy for a debilitating disease. The findings highlight the potential of verproside as a novel therapeutic agent for COPD.

Navigating the Desert of Lung Disease: A Targeted Approach

The study emphasizes the importance of targeting specific signaling pathways to effectively control inflammation in COPD. This is like identifying a hidden water source in the desert, providing a direct and efficient way to quench thirst. The findings underscore the need for further research into the therapeutic potential of verproside and other compounds that target specific signaling pathways involved in COPD.

Dr.Camel's Conclusion

This study offers a glimmer of hope in the vast desert of COPD research. The findings demonstrate the therapeutic potential of verproside, a naturally occurring compound, in reducing airway inflammation. This research encourages further exploration of verproside and other compounds that target specific signaling pathways, potentially leading to new and effective treatments for COPD.
Date :
  1. Date Completed 2023-05-02
  2. Date Revised 2023-05-02
Further Info :

Pubmed ID

37108390

DOI: Digital Object Identifier

PMC10138391

SNS
PICO Info
in preparation
Languages

English

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