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Pleiotropic effects of NOACs with focus on edoxaban: scientific findings and potential clinical implications.

Author: BöhmMichael, GoetteAndreas, LamparterMathias, MeierMartin, MollenhauerMartin, RudolphVolker

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses potential pleiotropic effects of edoxaban, a factor Xa inhibitor, beyond its anticoagulant properties. It highlights the role of factor Xa and thrombin in activating protease-activated receptors (PARs), which contribute to inflammation and fibrosis. Studies suggest that edoxaban may attenuate these pro-inflammatory and pro-fibrotic effects, potentially contributing to its beneficial outcomes in cardiovascular disease.
Paper Details　
Original Abstract of the Article :
Non-vitamin K antagonist oral anticoagulants (NOACs) are well-established as inhibitors of factor Xa (FXa) and thrombin in the treatment and prevention of thrombosis. However, there is growing evidence that beneficial outcomes might be based on additional pleiotropic effects beyond anticoagulation. ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229706/

データ提供：米国国立医学図書館（NLM）

Beyond Anticoagulation: Exploring the Pleiotropic Effects of NOACs

This research delves into the [pleiotropic effects of non-vitamin K antagonist oral anticoagulants (NOACs)] beyond their established role as inhibitors of [factor Xa (FXa) and thrombin]. The study aims to [investigate the potential of NOACs, particularly edoxaban, to modulate pro-inflammatory and pro-fibrotic pathways], which may contribute to the prevention of [atherosclerosis and fibrosis].

Edoxaban: A Multifaceted Agent with Potential Beyond Anticoagulation

The study reveals that [edoxaban exhibits pleiotropic effects, including the attenuation of FXa- and thrombin-induced pro-inflammatory and pro-fibrotic effects], suggesting a potential role in [atherosclerosis prevention]. These findings highlight the need for [further research to clarify the clinical implications of these pleiotropic effects] and to [evaluate the potential of edoxaban for treating and preventing cardiovascular disease].

A New Frontier in Cardiovascular Research: The Pleiotropic Potential of NOACs

This research expands our understanding of the [complex mechanisms of action of NOACs], opening new avenues for [therapeutic innovation and disease prevention]. The study emphasizes the importance of [considering the broader therapeutic potential of NOACs] beyond their anticoagulant properties.

Dr. Camel's Conclusion

My journey through the desert of cardiovascular research has revealed countless secrets, and this study, like a shimmering oasis, unveils a new dimension of NOACs. It's a reminder that even seemingly simple medications can harbor a multitude of effects, potentially offering benefits beyond their primary purpose. The study underscores the importance of embracing complexity in medical science and exploring the full potential of existing therapies.
Date :
  1. Date Completed 2023-06-01
  2. Date Revised 2023-06-02
Further Info :

Pubmed ID

37140824

DOI: Digital Object Identifier

PMC10229706

Related Literature

Article Analysis
・Effects of edoxaban
SNS
PICO Info
in preparation
Languages

English

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