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Ketogenic diet enhances the effects of oxycodone in mice.

Author: DiLeoneR J, DiazD M, FoscueE, TaylorJ R, ThompsonS L, TrinkoR

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The ketogenic diet (KD) has been shown to reduce pain and alcohol use disorder, but its effects on oxycodone responses are unknown. This study found that KD mice showed increased oxycodone-induced locomotor activity and enhanced antinociceptive effects of oxycodone, suggesting a dietary effect on opiate sensitivity. The effects were sex-specific, with male KD mice showing increased naloxone-induced jumps and reduced oxycodone self-administration.
Paper Details　
Original Abstract of the Article :
Opioids have been used to manage pain for thousands of years, but they have significant potential for abuse. Prescription opioids, like oxycodone, are associated with 32% of overdoses, that have reached a total of 75,673 deaths in 2021. A major challenge is maximizing their therapeutic potential whi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170077/

データ提供：米国国立医学図書館（NLM）

Ketogenic Diet: A Potential Ally in Opioid Pain Management and Addiction

The use of opioids to manage pain has a long history, but their potential for abuse and dependence poses a significant challenge. This study investigates the influence of the ketogenic diet (KD) on oxycodone responses in mice. The authors discovered that KD mice exhibited increased oxycodone-induced locomotor activity and enhanced antinociceptive effects of oxycodone, suggesting that the diet may modulate opioid sensitivity. Interestingly, they observed sex-specific effects of KD on opioid withdrawal and self-administration, highlighting the need for further investigation into the potential sex-specific effects of this dietary intervention.

Dietary Influence on Opioid Sensitivity: A Potential New Avenue for Pain Management

This research provides intriguing evidence that KD may enhance the therapeutic potential of oxycodone while potentially reducing its addictive potential. The sex-specific effects observed underscore the importance of personalized approaches to pain management and opioid addiction treatment.

The Ketogenic Diet: A Potential Tool for Optimizing Pain Management and Addiction Recovery

The ketogenic diet, while primarily known for its use in epilepsy, might also play a role in optimizing pain management and addiction recovery. This study suggests that KD could be a valuable tool for enhancing the effectiveness of opioids while potentially reducing their abuse liability. However, further research is needed to fully understand the implications of KD in both clinical pain management and addiction treatment.

Dr. Camel's Conclusion

The ketogenic diet, like a desert oasis offering refreshment and sustenance, may hold potential for enhancing the effectiveness of opioid pain management while mitigating their addictive properties. This research sheds light on the complex interplay between diet, opioid sensitivity, and addiction. Like a wise desert guide, further investigation is needed to ensure safe and effective application of this dietary intervention in clinical settings.
Date :
  1. Date Completed 2023-05-11
  2. Date Revised 2023-06-01
Further Info :

Pubmed ID

37160959

DOI: Digital Object Identifier

PMC10170077

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Article Analysis
・Side Effects of oxycodone
SNS
PICO Info
in preparation
Languages

English

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