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A Systematic Review of Systematic Reviews on the Use of Aromatase Inhibitors for the Treatment of Endometriosis: The Evidence to Date.

Author: GkegkesIoannis D, IavazzoChristos, LaganàAntonio Simone, LaiosAlexandros, PeitsidisPanagiotis, TsikourasPanagiotis

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Aromatase inhibitors (AIs) are potent drugs that suppress estrogen synthesis. This systematic review of systematic reviews and narrative reviews examines the use of AIs in the medical management of endometriosis. The review found that AIs can manage endometriosis-related symptoms in cases where initial medical management has failed, but their use is limited by the adverse effects that are linked with menopausal symptoms. Future studies with randomized design are needed to reach safer conclusions.
Paper Details　
Original Abstract of the Article :
Endometriosis is a chronic gynecologic condition that affects around 6-10% of reproductive age women. This clinical entity is characterized with pelvic pain, dysmenorrhea, dyspareunia, and infertility which are the most often presenting symptoms. Aromatase P450 is the key enzyme for ovarian estrogen...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166210/

データ提供：米国国立医学図書館（NLM）

Aromatase Inhibitors: A New Oasis in the Desert of Endometriosis

Endometriosis, a condition where tissue similar to the lining of the uterus grows outside the uterus, can feel like a harsh and unpredictable desert, often causing pain and impacting fertility. This study investigates the potential of aromatase inhibitors (AIs), medications that suppress estrogen production, as a treatment option for endometriosis.

A New Path Through the Desert of Endometriosis

This study suggests that AIs may be a viable option for managing endometriosis-related symptoms, particularly in cases where initial medical management has failed. However, the authors emphasize the need for further research to define optimal dosages, explore add-back therapies to mitigate side effects, and determine the most appropriate duration of treatment.

Finding Relief in the Desert of Endometriosis

If you're struggling with endometriosis, it's essential to seek professional medical advice to develop a personalized treatment plan that addresses your individual needs and goals.

Dr.Camel's Conclusion

This study provides a comprehensive review of the current evidence on the use of aromatase inhibitors for endometriosis. While they show promise for managing symptoms, further research is needed to optimize their use and ensure safe and effective treatment for all individuals affected by this condition.
Date :
  1. Date Completed 2023-06-02
  2. Date Revised 2023-06-02
Further Info :

Pubmed ID

37168488

DOI: Digital Object Identifier

PMC10166210

Related Literature

Article Analysis
・Effective treatment of endometriosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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