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Disruption of Glioblastoma Multiforme Cell Circuits with Cinnamaldehyde Highlights Potential Targets with Implications for Novel Therapeutic Strategies.

Author: BryantCrystal, HaynesCasey, KimYoo Na, NakhaiShadi A, PaiS Balakrishna, PatilKetki, SrivastavaShraddha, ThompsonElizabeth W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of cinnamaldehyde (CA) on glioblastoma multiforme (GBM) cell lines. The study found that CA exhibited equal potency in inhibiting GBM cells at both the cellular and molecular level, resulting in an increase in reactive oxygen species (ROS) and an increase in the apoptotic and multicaspase cell populations.
Paper Details　
Original Abstract of the Article :
Glioblastoma multiforme (GBM) is a major aggressive primary brain tumor with dismal survival outcome and few therapeutic options. Although Temozolomide (TMZ) is a part of the standard therapy, over time, it can cause DNA damage leading to deleterious effects, necessitating the discovery of drugs wit...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177046/

データ提供：米国国立医学図書館（NLM）

Disrupting Glioblastoma Multiforme Cell Circuits with Cinnamaldehyde

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with limited treatment options. This study investigated the potential of cinnamaldehyde (CA), a natural compound found in cinnamon, as a therapeutic agent for GBM. The researchers examined the effects of CA and its isomers/analogs on GBM cell lines U87 and U251, and the neuroglioma cell line H4.

Cinnamaldehyde: A Promising Anticancer Agent for Glioblastoma

The study found that CA and its isomers exhibited similar potency in inhibiting the viability of all three cell lines. CA treatment resulted in increased reactive oxygen species (ROS), apoptosis, and multicaspase cell populations. Furthermore, protein profiling revealed that CA downregulates key entities involved in glioblastoma cell circuits, such as pyruvate kinase-PKM2 and phosphomevalonate kinase.

Potential for Novel Therapeutic Strategies

These findings suggest that cinnamaldehyde could be a promising anticancer agent for glioblastoma. The researchers highlight the potential for CA to disrupt key metabolic pathways that are essential for GBM cell survival. They believe that this research opens up new avenues for developing novel therapeutic strategies for glioblastoma.

Dr. Camel's Conclusion

This study is like a desert explorer discovering a hidden oasis, offering a new source of hope for combating glioblastoma. The researchers have uncovered the potential of cinnamaldehyde as a therapeutic agent, providing a promising new direction for glioblastoma treatment.

Date :
  1. Date Completed 2023-05-15
  2. Date Revised 2023-05-15
Further Info :

Pubmed ID

37174677

DOI: Digital Object Identifier

PMC10177046

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SNS
PICO Info
in preparation
Languages

English

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