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Comparison of the effect of levonorgestrel-intrauterine system with or without oral megestrol acetate on fertility-preserving treatment in patients with atypical endometrial hyperplasia: A prospective, open-label, randomized controlled phase II study.

Author: ChenXiaojun, GuanJun, LiaoJiongbo, LuoXuezhen, MaFenghua, NingChengcheng, ShanWeiwei, ShaoWenyu, WuPengfei, XuZhiying, YangBingyi, ZhangHongwei, ZhouShuang, ZhuQin

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This randomized controlled trial compared the efficacy of levonorgestrel-intrauterine system (LNG-IUS) with or without oral megestrol acetate (MA) versus MA alone for atypical endometrial hyperplasia (AEH). There was no significant difference in complete response rate or other secondary endpoints between the groups. Further studies are needed with a larger sample size to confirm these findings.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare the effects of levonorgestrel-intrauterine system (LNG-IUS) with or without oral megestrol acetate (MA) versus MA alone on fertility-preserving treatment in patients with atypical endometrial hyperplasia (AEH). METHODS: This was a single-center phase II study with an open-labe...See full text at original site
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引用元：
https://doi.org/10.1016/j.ygyno.2023.05.001

データ提供：米国国立医学図書館（NLM）

Fertility-Preserving Treatment for Atypical Endometrial Hyperplasia

Atypical endometrial hyperplasia (AEH) is a precancerous condition that can affect a woman's fertility. This study investigates the efficacy of different fertility-preserving treatment options for AEH, comparing the effects of levonorgestrel-intrauterine system (LNG-IUS) with or without oral megestrol acetate (MA) versus MA alone.

Fertility-Preserving Treatments for Atypical Endometrial Hyperplasia: A Comparative Analysis

The study found that while all treatment groups showed some improvement, there was no significant difference in complete response (CR) rates between LNG-IUS with or without MA compared to MA alone. The study also noted that LNG-IUS was associated with fewer side effects compared to MA. These findings suggest that LNG-IUS might offer a potentially safer option for fertility-preserving treatment of AEH.

A Balancing Act: Fertility Preservation and Treatment Efficacy

This study highlights the challenges faced by healthcare providers in balancing the need for effective treatment of AEH with the desire to preserve fertility. The study's findings provide valuable insights into the comparative efficacy and safety of different treatment options, informing clinical decision-making for patients with AEH. Further research is needed to fully understand the long-term implications of these treatment strategies for both disease control and fertility preservation.

Dr.Camel's Conclusion

Fertility preservation is a delicate journey, akin to navigating a desert landscape with precious resources. This study offers a glimpse into the effectiveness of different treatment options for AEH, highlighting the potential benefits and drawbacks of each approach. While the findings suggest that LNG-IUS might be a safer option for fertility preservation, further research is needed to refine treatment strategies and provide a more comprehensive understanding of their long-term impacts. Ultimately, the goal is to find the most effective and safest path to both health and fertility for women with AEH.

Date :
  1. Date Completed 2023-06-27
  2. Date Revised 2023-06-27
Further Info :

Pubmed ID

37182434

DOI: Digital Object Identifier

10.1016/j.ygyno.2023.05.001

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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