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Analysis of Urinary Retention Caused by Selective β 3-adrenoceptor Agonists Using the Japanese Adverse Drug Event Report Database (JADER).

Author: IshidaT, JobuK, KawadaK, KawazoeT, MiyamuraM, YoshiokaS

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Selective β3-adrenoceptor agonists (sβ3-agonists) are effective in treating overactive bladder (OAB) with fewer side effects than traditional anti-muscarinics. This study analyzed data from the JADER database to assess the occurrence of adverse effects, particularly urinary retention, associated with sβ3-agonists. Urinary retention was the most frequently reported adverse effect, occurring more often in patients taking mirabegron/anti-muscarinic drugs compared to mirabegron monotherapy.
Paper Details　
Original Abstract of the Article :
Overactive bladder (OAB) is a frequent chronic disorder which impairs quality of life by frequent, uncontrollable urination. Newly developed selectiveβ 3-adrenoceptor agonists (sβ 3-agonists) have the same efficacy in treating OAB but significantly fewer side effects than the traditionally used anti...See full text at original site
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引用元：
https://doi.org/10.1691/ph.2023.3509

データ提供：米国国立医学図書館（NLM）

Unveiling the Potential Risks of β3-Adrenoceptor Agonists

This research investigates a fascinating area of [overactive bladder (OAB)] treatment. New drugs called [selective β3-adrenoceptor agonists (sβ3-agonists)] have emerged as a promising alternative to traditional anti-muscarinics, offering similar efficacy but with fewer side effects. However, this study delves into a potential pitfall: [urinary retention] – a condition where the bladder doesn’t empty properly.

A Closer Look at Urinary Retention

The study analyzed data from the [Japanese Adverse Drug Event Report Database (JADER)] and found that [urinary retention] was a significant side effect associated with sβ3-agonists. This finding underscores the importance of careful monitoring and consideration of individual risk factors, especially in patients with a history of [benign prostatic hypertrophy].

Navigating the Desert of OAB Treatment

Just like navigating a desert, the path to treating OAB can be challenging. This research sheds light on the potential risks associated with sβ3-agonists and emphasizes the importance of careful assessment, monitoring, and personalized treatment plans.

Dr.Camel's Conclusion

This research reminds us that, while new treatment options can offer hope, they also may carry their own set of challenges. Like a camel adapting to the harsh desert environment, healthcare providers need to be aware of the potential side effects of medications and adjust treatment plans accordingly. This way, we can ensure the best possible outcomes for our patients while navigating the ever-changing landscape of medical treatments.
Date :
  1. Date Completed 2023-05-17
  2. Date Revised 2023-05-23
Further Info :

Pubmed ID

37189265

DOI: Digital Object Identifier

10.1691/ph.2023.3509

SNS
PICO Info
in preparation
Languages

English

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