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Evaluation of mechlorethamine, vinblastine, procarbazine, and prednisone for the treatment of resistant multicentric canine lymphoma.

Author: AthertonMatthew J, FerrariJonathan T, KeulerNicholas S, LenzJennifer A, WalshKoranda A, ZimmermanKelley

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the clinical outcomes and toxicity of a modified MOPP chemotherapy regimen for dogs with relapsed or refractory multicentric lymphoma. The regimen included vinblastine instead of vincristine.
Paper Details　
Original Abstract of the Article :
Multi-agent chemotherapy successfully induces remission in most naïve, high-grade canine lymphoma patients; however, disease recurrence is common. MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) is an effective rescue protocol used to re-induce remission, but is associated with gas...See full text at original site
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引用元：
https://doi.org/10.1111/vco.12913

データ提供：米国国立医学図書館（NLM）

Canine Lymphoma: Exploring New Treatment Options

Cancer is a challenging diagnosis, even for our furry companions. This research investigates the effectiveness of a modified chemotherapy protocol for the treatment of resistant multicentric canine lymphoma. The study evaluated the use of mechlorethamine, vinblastine, procarbazine, and prednisone (MVPP) in dogs with relapsed or refractory lymphoma.

The study found that MVPP, while well tolerated, resulted in modest and transient clinical benefit. The overall response rate was 25%, with a median progression-free survival of 15 days and a median overall survival of 45 days. The researchers suggested that dose intensification could be considered to potentially improve clinical outcomes.

Canine Lymphoma: The Search for Effective Treatments

This research highlights the ongoing search for effective treatments for canine lymphoma. While MVPP showed some promise, it's important to note that further research is needed to determine its long-term efficacy and optimal dosing strategies.

Canine Lymphoma: Seeking Veterinary Care

If your dog is diagnosed with lymphoma, it's crucial to seek veterinary care from a qualified oncologist. They can develop a personalized treatment plan, taking into account your dog's individual needs and medical history.

Dr.Camel's Conclusion

This research reminds us that the journey to finding effective treatments for canine lymphoma is ongoing. Like a desert explorer seeking a hidden oasis of healing, researchers are constantly searching for better options to improve outcomes for our beloved companions.

Date :
  1. Date Completed 2023-08-16
  2. Date Revised 2023-08-16
Further Info :

Pubmed ID

37222086

DOI: Digital Object Identifier

10.1111/vco.12913

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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