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Metabolic changes in kidney stone disease.

Author: DuanChen, LiuHaoran, XuHua, XuZhenzhen, YaoXiangyang

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This manuscript summarizes the progress of research on metabolic changes in kidney stone disease and discusses the potential role of new therapeutic targets. It reviews the influence of metabolism of common substances like oxalate, reactive oxygen species (ROS), macrophage polarization, hormones, and other substances on stone formation.
Paper Details　
Original Abstract of the Article :
Kidney stone disease (KSD) is one of the earliest medical diseases known, but the mechanism of its formation and metabolic changes remain unclear. The formation of kidney stones is a extensive and complicated process, which is regulated by metabolic changes in various substances. In this manuscript,...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203412/

データ提供：米国国立医学図書館（NLM）

Metabolic Changes in Kidney Stone Disease: A Complex Landscape

The formation of kidney stones is a complex process, and understanding the underlying metabolic changes is crucial for developing effective treatments. Think of it like navigating a desert landscape, where different types of sand dunes represent various metabolic factors contributing to stone formation. The authors of this abstract reviewed the progress made in understanding the metabolic changes that occur in kidney stone disease (KSD). They discussed the role of various substances, such as oxalate, reactive oxygen species (ROS), and hormones, in stone formation.

Metabolic Changes: A Key to Understanding KSD

The authors highlighted several metabolic changes that are involved in stone formation. These include alterations in oxalate metabolism, increased ROS production, and changes in macrophage polarization. They also discussed the influence of hormones and other substances on stone formation. This research provides a valuable overview of the complex metabolic processes involved in KSD.

Implications for Patients

Understanding the metabolic changes involved in KSD can help clinicians to develop personalized treatment plans for patients. This can involve dietary modifications, medications, and other interventions aimed at addressing specific metabolic imbalances.

Dr.Camel's Conclusion

This abstract offers a glimpse into the complex metabolic desert that is KSD. The authors have provided a comprehensive overview of the key metabolic factors involved in stone formation. This research is crucial for developing new and effective treatments for KSD and improving the lives of patients struggling with this condition.

Date :
  1. Date Completed 2023-05-29
  2. Date Revised 2023-05-30
Further Info :

Pubmed ID

37228601

DOI: Digital Object Identifier

PMC10203412

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・Effective treatment of kidney stones
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PICO Info
in preparation
Languages

English

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