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Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression.

Author: AndreassenOle A, BahramiShahram, ChengWeiqiu, DaleAnders M, DjurovicSrdjan, FilizTahir T, FreiOleksandr, HagenEspen, HindleyGuy, HolenBørge, IcickRomain, JahołkowskiPiotr, KaradagNaz, O'ConnellKevin S, ParkerNadine, RødevandLinn, ShadrinAlexey A, SmelandOlav B, TesfayeMarkos

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study explores the shared genetic architecture between opioid use disorder (OUD) and mental disorders like schizophrenia (SCZ), bipolar disorder (BD), and major depression (MD). Genetic overlap was identified between OUD and these psychiatric disorders, suggesting shared neurobiological pathways.
Paper Details　
Original Abstract of the Article :
Opioid use disorder (OUD) and mental disorders are often comorbid, with increased morbidity and mortality. The causes underlying this relationship are poorly understood. Although these conditions are highly heritable, their shared genetic vulnerabilities remain unaccounted for. We applied the condit...See full text at original site
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引用元：
https://doi.org/10.1111/adb.13282

データ提供：米国国立医学図書館（NLM）

Unraveling the Shared Genetic Roots of Opioid Use Disorder and Mental Illness

Opioid use disorder (OUD) and mental illnesses often coexist, presenting a significant challenge for both individuals and healthcare systems. This study delves into the complex genetic relationship between OUD and mental disorders, aiming to uncover shared genetic vulnerabilities that might explain their frequent comorbidity.

Shared Genetic Pathways: Bridging the Gap Between OUD and Mental Illness

Using a powerful genetic analysis approach, the study identified significant genetic overlap between OUD and mental disorders like schizophrenia (SCZ), bipolar disorder (BD), and major depression (MD). The researchers discovered 14 novel OUD loci and 7 unique loci shared with these mental disorders, suggesting that shared genetic pathways might underlie the comorbidity. This research is like finding a hidden trail in the desert – a path that connects the seemingly disparate landscapes of OUD and mental illness.

Understanding the Connections: A Key to Effective Treatment

The study's findings provide valuable insights into the complex interplay between OUD and mental disorders, suggesting that shared genetic vulnerabilities might contribute to their frequent coexistence. This understanding is crucial for developing more effective and personalized treatment strategies for these interconnected conditions. It's like discovering a hidden oasis in the desert of mental health – a source of understanding and potential for more effective treatment approaches.

Dr.Camel's Conclusion

This study illuminates the complex genetic relationship between OUD and mental illnesses, offering a deeper understanding of their frequent comorbidity. This research is a beacon of hope in the desert of mental health, suggesting that a more integrated approach to treatment might be necessary for individuals struggling with both OUD and mental disorders. It's a reminder that the journey towards better mental health requires a holistic understanding of the interconnectedness of these conditions.
Date :
  1. Date Completed 2023-06-01
  2. Date Revised 2023-06-06
Further Info :

Pubmed ID

37252880

DOI: Digital Object Identifier

10.1111/adb.13282

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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