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Rotary pursuit, a measure of human performance, and plasma concentrations of promethazine.

Author: BrownW J, FranciscoG E, HonigbergI L, KotzanJ A, StewartJ T, ZamanR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Promethazine, at doses of 50 mg, impaired human motor performance, as measured by rotary pursuit and reaction time tasks. The degree of impairment was linearly related to the promethazine blood concentration.
Paper Details　
Original Abstract of the Article :
Promethazine in doses of 50 mg has demonstrated detrimental effects upon the performance of visual tasks. The purpose of the study was to examine the relationship between the blood concentration levels of promethazine and two human performance tasks. Fifteen paid healthy male volunteers completed a ...See full text at original site
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引用元：
https://doi.org/10.1002/bdd.2510070310

データ提供：米国国立医学図書館（NLM）

Promethazine's Impact on Human Performance: A Dose-Dependent Effect

This study investigated the effect of promethazine, an antihistamine medication, on human performance, specifically focusing on rotary pursuit and reaction time tasks. The research revealed a clear dose-dependent relationship between promethazine levels in the blood and performance impairment. Higher doses of promethazine led to more significant decreases in rotary pursuit performance and reaction time. This study emphasizes the importance of considering the potential impact of medications, even those used for seemingly benign conditions, on human performance, especially in tasks requiring precision and coordination.

Promethazine: Navigating the Trade-Offs

This study provides valuable insights into the potential impact of medications on human performance. While promethazine can effectively treat various conditions, it's important to be aware of its potential to affect motor skills and cognitive function. It's crucial to discuss any concerns about medication effects with your healthcare provider and make informed decisions about your treatment plan.

Implications for Everyday Life

If you're prescribed promethazine, it's essential to be mindful of its potential effects on your ability to drive, operate machinery, or engage in activities requiring precise coordination. Communicate openly with your doctor about any concerns you have and discuss ways to manage potential side effects, ensuring that you can continue to live a fulfilling life while managing your health condition effectively.

Dr. Camel's Conclusion

Imagine a camel navigating a sandy desert, its every step influenced by the shifting dunes. Just as the landscape can affect a camel's movement, promethazine can impact human performance. This study reveals a dose-dependent effect, highlighting the importance of careful consideration when taking medications. By understanding the potential impact, we can navigate the desert of medication effects with greater awareness and control.

Date :
  1. Date Completed 1986-09-16
  2. Date Revised 2019-10-22
Further Info :

Pubmed ID

3730529

DOI: Digital Object Identifier

10.1002/bdd.2510070310

Related Literature

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・Effects of promethazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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