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Long-term deprescription in chronic pain and opioid use disorder patients: Pharmacogenetic and sex differences.

Author: BarrachinaJordi, CarvajalCristian, EscorialMónica, MargaritCésar, MoralesDomingo, MurielJavier, PeiróAna M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study analyzed the long-term effectiveness of opioid deprescription in patients with chronic non-cancer pain. The deprescription was successful in 49% of patients, with an increase in pain relief and a reduction of adverse events. The study also highlights the influence of sex and pharmacogenetics on opioid deprescription success.
Paper Details　
Original Abstract of the Article :
More than half of patients with opioid use disorder for chronic non-cancer pain (CNCP) reduced their dose through a progressive opioid withdrawal supported by a rotation to buprenorphine and/or tramadol. The aim of this research is to analyse the long-term effectiveness of opioid deprescription taki...See full text at original site
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引用元：
https://doi.org/10.2478/acph-2023-0018

データ提供：米国国立医学図書館（NLM）

Opioid Deprescription: A Long and Winding Road

Opioids are powerful pain relievers, but they can also be addictive. This research focuses on the long-term effectiveness of opioid deprescription, the process of gradually reducing opioid use, in patients with chronic pain and opioid use disorder. Imagine it like a long journey through the desert, where the goal is to safely navigate away from dependence on opioids.

Factors Affecting Success

The study explores the impact of sex and pharmacogenetics on the effectiveness of opioid deprescription. It's like understanding the different terrain in the desert, where some individuals might find it easier to navigate the withdrawal process than others. The study found that women may experience a higher degree of opioid deprescription, but also face unique challenges and side effects.

Personalized Strategies for Success

This research highlights the importance of personalized strategies for opioid deprescription, taking into account individual factors such as sex, genetics, and pain levels. It's like having a map that guides you through the desert, tailored to your specific needs and vulnerabilities.

Dr. Camel's Conclusion

The journey of opioid deprescription is often challenging, but this research sheds light on important factors that can influence success. It's a reminder that we need to approach pain management and addiction with compassion and a personalized approach.

Date :
  1. Date Completed 2023-06-14
  2. Date Revised 2023-06-14
Further Info :

Pubmed ID

37307374

DOI: Digital Object Identifier

10.2478/acph-2023-0018

Related Literature

Article Analysis
・Side Effects of tramadol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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