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Effects of buspirone and diazepam, alone and in combination with alcohol, on skilled performance and evoked potentials.

Author: ErwinA, ErwinC W, GuthrieS, HartwellJ, LinnoilaM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Buspirone, compared to diazepam, had lesser effects on skilled performance and evoked responses. Buspirone's effects were primarily sedative and short-lasting, while diazepam also impaired tracking and body balance. Both anxiolytics showed slight additive interactions with alcohol.
Paper Details　
Original Abstract of the Article :
Effects of buspirone, 10 and 20 mg, and diazepam, 10 mg, on skilled performance and evoked responses, as well as their interactions with 0.8 g/kg of alcohol were investigated in 24 healthy men. Alcohol, 0.8 g/kg, caused the greatest performance impairment, followed closely by diazepam. Both doses of...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3734141

データ提供：米国国立医学図書館（NLM）

Investigating the Effects of Anxiolytics on Skilled Performance and Evoked Potentials

This research delves into the realm of psychopharmacology, exploring the effects of anxiolytics, specifically buspirone and diazepam, on cognitive function and brain activity. The study employed a controlled experimental design to assess the impact of these drugs on skilled performance, as measured by tracking tasks and balance tests, and on evoked potentials, which reflect brain responses to stimuli. The researchers sought to understand the individual and combined effects of these anxiolytics on cognitive function and the neural mechanisms underlying these effects.

Anxiolytics Impact Cognitive Function and Brain Activity

The study revealed that both buspirone and diazepam, albeit to varying degrees, influenced skilled performance and brain activity. Diazepam had a more pronounced impact on cognitive function, while buspirone primarily showed sedative effects. The researchers observed additive effects when alcohol was combined with these anxiolytics, emphasizing the need for caution when consuming alcohol while on these medications. The study also highlighted potential differences in the way these anxiolytics interact with the brain, as observed in the evoked potential measurements.

Considerations for Anxiolytic Use

The study's findings underscore the importance of considering the potential cognitive effects of anxiolytics. It highlights the need for caution, especially when combining these medications with alcohol, as this can lead to increased impairment. Understanding the individual effects of different anxiolytics and their interactions with other substances can help individuals make informed decisions about their medication choices.

Dr.Camel's Conclusion

This research provides valuable insights into the complex interactions between anxiolytics, alcohol, and cognitive function. It reminds us that even seemingly benign substances like alcohol can interact with medications in unpredictable ways. The researchers' findings encourage us to approach medication choices with awareness and careful consideration, ensuring that we navigate the complexities of mind-altering substances with caution and knowledge.

Date :
  1. Date Completed 1986-09-19
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3734141

DOI: Digital Object Identifier

3734141

Related Literature

Article Analysis
・Effects of diazepam・Effects of buspirone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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