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Tripterine inhibits proliferation and promotes apoptosis of keloid fibroblasts by targeting ROS/JNK signaling.

Author: HuangFang, LeiYan, XueChengbin, YanQiong, ZhangEnjing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This research investigates the therapeutic effects of tripterine, a natural triterpene, on keloid fibroblasts. Tripterine effectively inhibited keloid fibroblast proliferation, migration, and extracellular matrix deposition, while promoting apoptosis. These effects were mediated by increased ROS generation and activation of the JNK signaling pathway. The findings suggest that tripterine has potential as a therapeutic agent for the treatment of keloids by targeting the pathological processes involved in their formation and growth.
Paper Details　
Original Abstract of the Article :
Keloids are benign skin tumors characterized by excessive fibroblast proliferation and collagen deposition. The current treatment of keloids with hormone drug injection, surgical excision, radiotherapy, physical compression, laser therapy, cryotherapy often have unsatisfactory outcomes. The phytoche...See full text at original site
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引用元：
https://doi.org/10.1093/jbcr/irad106

データ提供：米国国立医学図書館（NLM）

Tripterine: A Natural Compound with Potential for Keloid Treatment

Keloids, benign skin tumors characterized by excessive collagen deposition, can be a challenging and frustrating condition for individuals. This study investigates the potential of tripterine, a natural compound derived from a traditional Chinese medicine, in treating keloids. The researchers, like skilled herbalists seeking effective remedies, explored the effects of tripterine on keloid fibroblasts, the cells responsible for the overgrowth of collagen in keloids.

The researchers found that tripterine effectively inhibited the proliferation and promoted apoptosis of keloid fibroblasts. They also identified the specific signaling pathways involved in this process, revealing how tripterine exerts its anti-keloid effects. This discovery holds promise for the development of new treatments for keloids, offering a potential alternative to existing approaches.

Harnessing Nature's Healing Power

This study highlights the potential of natural compounds for treating keloids. The researchers' findings suggest that tripterine, derived from a traditional Chinese medicine, could offer a safe and effective alternative for treating this common condition. This discovery underscores the importance of exploring natural remedies and traditional medicine for their potential therapeutic benefits.

The Promise of Natural Remedies

This study serves as a reminder that nature holds a wealth of potential remedies for various conditions. The researchers' findings suggest that tripterine, a natural compound, could be a promising therapeutic agent for treating keloids. This discovery encourages further research into the potential of natural compounds for treating various diseases and conditions.

Dr.Camel's Conclusion

The desert landscape of traditional Chinese medicine is rich with potential remedies. Tripterine, like a hidden gem, holds promise for treating keloids. This research shows that natural compounds can offer effective and safe alternatives for treating various conditions, encouraging us to explore the vast and untapped potential of nature's healing power.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-07-12
Further Info :

Pubmed ID

37436955

DOI: Digital Object Identifier

10.1093/jbcr/irad106

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