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The effect of valacyclovir on secondary prevention of congenital cytomegalovirus infection, following primary maternal infection acquired periconceptionally or in the first trimester of pregnancy. An individual patient data meta-analysis.

Author: AmirJacob, ChatzakisChristos, EgloffCharles, Faure-BardonValentine, HadarEran, Leruez-VilleMarianne, PiconeOlivier, Shahar-NissanKaren, SotiriadisAlexandros, VilleYves, VivantiAlexandre

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This meta-analysis aims to assess the effectiveness and safety of valacyclovir treatment for preventing congenital cytomegalovirus infection in pregnant women.
Paper Details　
Original Abstract of the Article :
Recent studies have shown that a dosage of 8 g/d of oral valacyclovir reduces substantially the vertical transmission rate of cytomegalovirus in women with primary cytomegalovirus infection acquired periconceptionally or during the first trimester of pregnancy. This individual patient data meta-anal...See full text at original site
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引用元：
https://doi.org/10.1016/j.ajog.2023.07.022

データ提供：米国国立医学図書館（NLM）

Valacyclovir for Congenital Cytomegalovirus Infection: A Promising Secondary Prevention Strategy

Congenital cytomegalovirus (CMV) infection is a significant concern for pregnant women, particularly those with primary CMV infection acquired periconceptionally or during the first trimester. This study examines the effectiveness of valacyclovir in reducing the vertical transmission rate of CMV.

A Meta-Analysis of Valacyclovir's Impact on Congenital CMV

The meta-analysis, based on individual patient data, demonstrates the significant impact of valacyclovir in reducing the risk of congenital CMV infection. The study highlights the potential of valacyclovir as a valuable secondary prevention strategy for pregnant women with primary CMV infection.

Protecting Infants from Congenital CMV

This research provides strong evidence for the use of valacyclovir in reducing the risk of congenital CMV infection. The findings have significant implications for clinical practice, offering a promising tool for preventing this serious condition in infants.

Dr.Camel's Conclusion

This study, like a desert oasis providing vital hydration, offers a beacon of hope in the fight against congenital CMV. Valacyclovir emerges as a valuable tool for protecting infants from this serious condition, highlighting the power of research to improve maternal and infant health.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-08-10
Further Info :

Pubmed ID

37473793

DOI: Digital Object Identifier

10.1016/j.ajog.2023.07.022

Related Literature

Article Analysis
・Effects of valacyclovir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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