Effects of valacyclovir: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Major Research Findings

Valacyclovir is an antiviral drug commonly used to treat herpesvirus infections. Many studies have shown that valacyclovir is effective in reducing the symptoms of herpesvirus infections and suppressing viral replication. 12 reported that valacyclovir can reduce pain associated with shingles. 2 reported that valacyclovir increased CD4 cell counts in pregnant and postpartum women co-infected with HIV-1/HSV-2 and suppressed HIV-1 replication. 5 reported that valacyclovir reduced the severity of herpes simplex virus type 1 (HSV-1) infection in mice. 6 reported that valacyclovir is not effective in treating feline herpesvirus 1 (FHV-1) infection in cats. 11 suggested that valacyclovir may be effective in treating non-small cell lung cancer. 3 suggested that valacyclovir may be effective in treating Bell's palsy. 8 suggested that valacyclovir may be effective in preventing cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. reported that valacyclovir may cause catatonia. 9 suggested that valacyclovir may be effective in preventing and treating cytomegalovirus infection during pregnancy. showed that valacyclovir and famciclovir were equally effective in reducing the severity of HSV-1 infection in mice. 1 suggested that valacyclovir may have an anti-seizure effect in patients with epilepsy. 4 reported that valacyclovir is effective in preventing cytomegalovirus infection in HIV-infected individuals. 7 reported that valacyclovir and acyclovir may cause severe cutaneous adverse events. 13 reported that valacyclovir is effective in reducing the vertical transmission rate of cytomegalovirus in pregnant women. reported that valacyclovir is effective in preventing cytomegalovirus transmission in pregnant women. 10 showed that a nanoformulation of valacyclovir may enhance antiviral effects against herpes simplex viruses.

Benefits and Risks

Benefit Summary

Many studies have shown that valacyclovir is effective in treating herpesvirus infections. Valacyclovir reduces symptoms of herpesvirus infection and suppresses viral replication. Valacyclovir is also expected to reduce pain associated with shingles, increase CD4 cell counts in pregnant and postpartum women co-infected with HIV-1/HSV-2, and suppress HIV-1 replication. 12 , 2 , 5 , 11 , 3 , 8 , , 10

Risk Summary

Valacyclovir can cause side effects. 6 showed that valacyclovir is toxic to cats and not suitable for treatment. reported that valacyclovir may cause catatonia. 7 reported that valacyclovir and acyclovir may cause severe cutaneous adverse events.

Study Comparisons

Commonalities Among Studies

Many studies have shown that valacyclovir is effective in treating herpesvirus infections. Valacyclovir reduces symptoms of herpesvirus infection and suppresses viral replication. Valacyclovir has also been shown to be effective in preventing herpesvirus infections.

Differences Among Studies

The effects of valacyclovir vary depending on the virus and patient. 6 showed that valacyclovir is toxic to cats and not suitable for treatment. 5 reported that valacyclovir reduced the severity of herpes simplex virus type 1 (HSV-1) infection in mice, but 11 suggested that valacyclovir may be effective in treating non-small cell lung cancer. Thus, the effects of valacyclovir vary depending on the virus and patient.

Consistency and Contradictions in Findings

Many studies have shown that valacyclovir is an effective drug for treating herpesvirus infections. However, valacyclovir does not work for all patients and may cause side effects. The effects of valacyclovir also vary depending on the virus and patient. Therefore, valacyclovir should be used only under the direction of a physician.

Practical Applications and Cautions

Valacyclovir is an effective drug for treating herpesvirus infections, but it also has the potential to cause side effects. Valacyclovir should be used only under the direction of a physician. Valacyclovir should be used with caution in pregnant or breastfeeding women, patients with kidney or liver disease, and patients taking other medications.

Limitations of Current Research

More research is needed on the effects of valacyclovir. In particular, research on long-term effects and side effects is lacking. The effects of valacyclovir vary depending on the virus and patient, so further research is needed.

Future Research Directions

Further research is needed on the effects of valacyclovir. In particular, research on long-term effects and side effects is needed. The effects of valacyclovir vary depending on the virus and patient, so further research is needed. New formulations of valacyclovir are also expected to be developed.

Conclusion

Many studies have shown that valacyclovir is an effective drug for treating herpesvirus infections. However, valacyclovir does not work for all patients and may cause side effects. Valacyclovir should be used only under the direction of a physician. Through further research, it is important to gain a deeper understanding of the safety and efficacy of valacyclovir.

Literature analysis of 13 papers
Positive Content
10
Neutral Content
0
Negative Content
3
Article Type
4
2
2
2
13
2.

Effects of valacyclovir on markers of disease progression in postpartum women co-infected with HIV-1 and herpes simplex virus-2.

Author: RoxbyAlison C, DrakeAlison L, Ongecha-OwuorFrancisca, KiarieJames N, RichardsonBarbra, MatemoDaniel N, OverbaughJulie, EmerySandra, John-StewartGrace C, WaldAnna, FarquharCarey

Increased CD4
Reduced HIV RNA

Valacyclovir suppression during pregnancy and postpartum resulted in greater increases in CD4 counts and smaller increases in plasma HIV-1 RNA levels compared to placebo in HIV-1/HSV-2 co-infected women.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Reactivation of herpes simplex virus type 1 and varicella-zoster virus and therapeutic effects of combination therapy with prednisolone and valacyclovir in patients with Bell's palsy.

Author: KawaguchiKazuhiro, InamuraHiroo, AbeYasuhiro, KoshuHidehiro, TakashitaEmi, MurakiYasushi, MatsuzakiYoko, NishimuraHidekazu, IshikawaHitoshi, FukaoAkira, HongoSeiji, AoyagiMasaru

Bell's palsy

Reactivation of herpes simplex virus (HSV) type 1 or varicella-zoster virus (VZV) was observed in 34% of patients with Bell's palsy. Combination therapy with prednisolone and valacyclovir did not improve recovery rates compared to prednisolone alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Quantitative effects of valacyclovir on the replication of cytomegalovirus (CMV) in persons with advanced human immunodeficiency virus disease: baseline CMV load dictates time to disease and survival. The AIDS Clinical Trials Group 204/Glaxo Wellcome 123-014 International CMV Prophylaxis Study Group.

Author: EmeryV C, SabinC, FeinbergJ E, GrywaczM, KnightS, GriffithsP D

Virus load suppression
Increased risk of disease

Elevated CMV load in blood and urine at baseline was associated with increased risk of HCMV disease and a shorter survival time. Valacyclovir significantly suppressed the virus load in subjects who were PCR positive at baseline.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

The comparative effects of famciclovir and valacyclovir on herpes simplex virus type 1 infection, latency, and reactivation in mice.

Author: LeBlancR A, PesnicakL, GodleskiM, StrausS E

Reduced mortality
Reduced viral shedding

Famciclovir and valacyclovir were equally effective in limiting the virulence and spread of HSV-1 in a mouse eye model of HSV infection.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

Effects of valacyclovir in cats infected with feline herpesvirus 1.

Author: NasisseM P, DormanD C, JamisonK C, WeiglerB J, HawkinsE C, StevensJ B

FHV-1 replication
Toxicity

Valacyclovir was found to be toxic to cats with primary feline herpesvirus 1 (FHV-1) infection, even at high doses, and did not suppress viral replication.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis.

Author: Rybak-KrzyszkowskaMagda, GóreckaJoanna, HurasHubert, Massalska-WolskaMagdalena, StaśkiewiczMagdalena, GachAgnieszka, KondrackaAdrianna, StaniczekJakub, GórczewskiWojciech, BorowskiDariusz, JaczyńskaRenata, GrzesiakMariusz, KrzeszowskiWaldemar

Early detection of CMV
Prevention and management
Developmental delays

This study examines the impact of cytomegalovirus (CMV) infection during pregnancy, highlighting its significance as a leading cause of health problems and developmental delays in infants. It discusses the management, prevention strategies, and treatment options for CMV infection in expectant mothers.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

A Network Meta-Analysis of Randomized Clinical Trials to Assess the Efficacy and Safety of Antiviral Agents for Immunocompetent Patients with Herpes Zoster-Associated Pain.

Author: LiuYidan, XiaoShufang, LiJiamin, LongXia, ZhangYuqing, LiXiaofeng

Improved HZ management
Reduced pain

This article explores the best approach to prevent herpes zoster (HZ)-associated pain, a common and debilitating symptom. While early use of antiviral medications has shown to be effective in reducing pain across all stages of the disease, the optimal approach remains uncertain.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

The effect of valacyclovir on secondary prevention of congenital cytomegalovirus infection, following primary maternal infection acquired periconceptionally or in the first trimester of pregnancy. An individual patient data meta-analysis.

Author: ChatzakisChristos, Shahar-NissanKaren, Faure-BardonValentine, PiconeOlivier, HadarEran, AmirJacob, EgloffCharles, VivantiAlexandre, SotiriadisAlexandros, Leruez-VilleMarianne, VilleYves

Reduced congenital CMV infection

This meta-analysis aims to assess the effectiveness and safety of valacyclovir treatment for preventing congenital cytomegalovirus infection in pregnant women.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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