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Azithromycin alters Colony Stimulating Factor-1R (CSF-1R) expression and functional output of murine bone marrow-derived macrophages: A novel report.

Author: Agrawal-RajputReena, DalaiParmeswar, GowdaSharath, NivsarkarManish, YadavShivani

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Azithromycin treatment led to an increased generation of M2-skewed macrophages, which had altered functions, including decreased pro-inflammatory cytokine release and increased anti-inflammatory IL-10 release. This effect was independent of azithromycin's antibacterial actions.
Paper Details　
Original Abstract of the Article :
Antibiotic treatment may lead to side effects that require mechanistic explanation. We investigated the effect of azithromycin (AZM) treatment on bone marrow-derived macrophage (Mφ) generation, their functional output, and the subsequent effect on bacterial clearance in a mouse model of S. flex...See full text at original site
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引用元：
https://doi.org/10.1016/j.intimp.2023.110688

データ提供：米国国立医学図書館（NLM）

Azithromycin and Its Impact on Macrophages

This research dives into the fascinating world of the immune system, a complex network that protects us from invaders. This study investigates the impact of azithromycin, a common antibiotic, on macrophages, a type of immune cell that acts like a scavenger, cleaning up debris and fighting off pathogens. It's like observing the impact of a sandstorm on a desert ecosystem, exploring how it can affect the delicate balance of life.

Azithromycin Alters Macrophage Function

The researchers found that azithromycin can alter the behavior of macrophages, potentially influencing their ability to fight off infection. It's like a shift in the desert wind, affecting the direction of the sands and influencing the landscape. The study found that azithromycin can skew macrophages towards an anti-inflammatory state, potentially impacting their ability to fight infection and contributing to a less effective immune response.

Navigating the Desert of Infection

This research offers valuable insight into the complex interplay between antibiotics and the immune system. It suggests that azithromycin, while effective against bacteria, might also have unintended consequences for the immune system. It's important to consult with a healthcare professional to understand the potential risks and benefits of antibiotic use and to ensure that any antibiotic treatment is appropriate for your individual needs.

Dr. Camel's Conclusion

This research explores the intricate world of the immune system, a complex and dynamic desert ecosystem. The study highlights the impact of azithromycin on macrophages, demonstrating the importance of understanding the potential consequences of antibiotics on the delicate balance of the immune system.
Date :
  1. Date Completed 2023-09-27
  2. Date Revised 2023-09-27
Further Info :

Pubmed ID

37499396

DOI: Digital Object Identifier

10.1016/j.intimp.2023.110688

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・Side Effects of azithromycin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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