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Duration of Adjunctive Antidepressant Maintenance in Bipolar I Depression.
Author: , AhnYong Min, ArumughamShyam Sundar, AshokMysore V, BeaulieuSerge, BhandaryR P, BondDavid J, DaigneaultAndrée, FreyBenicio N, HaKyooseob, KesavanMuralidharan, KondapuramNithin, LamRaymond W, MilevRoumen, MurthyNithyananda S, OuyangYongdong, RamachandranKanchana, RavindranArun, RavindranNisha, ReddyM S, ReddyY C Janardhan, SarafGayatri, SchafferAyal, WongHubert, YathamLakshmi N
Original Abstract of the Article :
BACKGROUND: Antidepressants are used to treat acute depression in patients with bipolar I disorder, but their effect as maintenance treatment after the remission of depression has not been well studied. METHODS: We conducted a multisite, double-blind, randomized, placebo-controlled trial of mainten...See full text at original site
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引用元：
https://doi.org/10.1056/NEJMoa2300184
データ提供：米国国立医学図書館（NLM）
Antidepressant Maintenance in Bipolar I Depression: A Shifting Sandscape
Bipolar disorder research seeks to understand and manage the complex mood swings and depressive episodes associated with this condition. This multisite, double-blind, randomized, placebo-controlled trial examines the effectiveness of maintenance antidepressant therapy in preventing relapse in patients with bipolar I disorder who have recently achieved remission of a depressive episode. The authors randomly assigned 150 patients to either continue treatment with escitalopram or bupropion XL for 52 weeks or switch to placebo at 8 weeks. The trial was stopped early due to slow recruitment and funding limitations. The analysis found no significant benefit of continuing antidepressant treatment for 52 weeks compared to 8 weeks in preventing relapse of any mood episode.
A Complex Journey: Antidepressant Maintenance in Bipolar I Disorder
The study’s findings highlight the complex nature of bipolar disorder and the ongoing need for research into effective relapse prevention strategies.
Navigating the Desert of Bipolar Disorder
As a psychiatrist specializing in mood disorders, I am constantly seeking ways to improve the management of bipolar disorder. This study provides valuable insights into the effectiveness of antidepressant maintenance therapy in preventing relapse. While the study’s findings are inconclusive, they underscore the need for further research to better understand the role of antidepressants in long-term management of bipolar I disorder.
Dr. Camel's Conclusion
This multisite, double-blind, randomized, placebo-controlled trial examines the effectiveness of maintenance antidepressant therapy in preventing relapse in patients with bipolar I disorder who have recently achieved remission of a depressive episode. The trial was stopped early due to slow recruitment and funding limitations. The analysis found no significant benefit of continuing antidepressant treatment for 52 weeks compared to 8 weeks in preventing relapse of any mood episode.
Date :
- Date Completed 2023-08-03
- Date Revised 2023-12-13
Further Info :
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