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Autophagy Inhibition via Hydroxychloroquine or 3-Methyladenine Enhances Chemotherapy-Induced Apoptosis in Neuro-Blastoma and Glioblastoma.

Author: BalachandarArpana, BhagirathEesha, PandeySiyaram, VeghCaleb, WearDarcy

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Neuroblastoma and glioblastoma are childhood cancers with poor prognoses. This study investigated the effects of autophagic alterations in combination with standard chemotherapies. Autophagy inhibition enhanced apoptosis and oxidative stress, potentially improving treatment outcomes.
Paper Details　
Original Abstract of the Article :
Neuroblastoma is the most common tumour in children under 1 year old, accounting for 12-15% of childhood cancer deaths. Although current treatments are relatively efficacious against this cancer, associated adverse effects could be detrimental to growth and development. In contrast, glioblastoma acc...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418453/

データ提供：米国国立医学図書館（NLM）

Autophagy Inhibition: A Potential Weapon Against Neuroblastoma and Glioblastoma

Cancer is a formidable foe, and finding effective treatments is a constant challenge. This study explored the potential of targeting autophagy, a cellular process for degrading and recycling components, to enhance chemotherapy-induced apoptosis in neuroblastoma and glioblastoma. The researchers found that autophagy inhibition using hydroxychloroquine or 3-methyladenine alongside standard chemotherapies significantly enhanced apoptosis in both cancer cell lines.

Targeting Autophagy: A New Frontier in Cancer Treatment

This research suggests that autophagy inhibition could be a promising strategy for improving the effectiveness of chemotherapy in treating neuroblastoma and glioblastoma. The study's findings pave the way for further research to develop targeted therapies that combine autophagy modulation with existing chemotherapies.

Cancer Treatment: A Journey Through the Desert of Disease

Cancer is like a relentless sandstorm, sweeping through the body and leaving a trail of destruction. This research offers a potential oasis of hope, exploring new avenues for combating this devastating disease.

Dr.Camel's Conclusion

The desert of cancer can be a bleak and unforgiving landscape. This research offers a glimmer of hope, suggesting that targeting autophagy could provide a powerful new weapon in the fight against this formidable foe.

Date :
  1. Date Completed 2023-08-14
  2. Date Revised 2023-08-14
Further Info :

Pubmed ID

37569432

DOI: Digital Object Identifier

PMC10418453

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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