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Efficacy and safety of lemborexant in subjects previously treated with placebo for 6 months in a randomized phase 3 study.

Author: InoueYuichi, KubotaNaoki, MolineMargaret, PerdomoCarlos, PerlisMichael L, PinnerKate, YardleyJane

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lemborexant 5 mg and 10 mg showed sustained clinical gains in sleep outcomes even after extended placebo treatment. The safety profile was similar between treatment periods and groups.
Paper Details　
Original Abstract of the Article :
OBJECTIVE/BACKGROUND: To examine the effects of lemborexant (LEM) 5 mg (LEM5) or LEM 10 mg (LEM10) following extended placebo treatment. This post-hoc analysis used subject-reported sleep outcomes data from a phase 3 trial. PATIENTS/METHODS: The subjects in these post-hoc analyses were randomized t...See full text at original site
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引用元：
https://doi.org/10.1016/j.sleep.2023.07.023

データ提供：米国国立医学図書館（NLM）

Lemborexant: Easing Insomnia's Grip

The desert of [insomnia] can be a lonely and isolating place, my friend. This study investigates the potential of [lemborexant] for treating insomnia, a condition that affects millions worldwide. The researchers conducted a post-hoc analysis of a previous study and found that lemborexant, a [dual orexin receptor antagonist], showed sustained improvements in sleep quality, even after subjects had received placebo for six months. It's like finding a hidden oasis in the desert – a source of relief that can help to restore balance and improve well-being.

A New Oasis for Insomnia

This study offers a ray of hope for those struggling with insomnia. The researchers have found that lemborexant can provide sustained improvements in sleep quality, even after subjects had initially responded to placebo. This suggests that lemborexant could be a valuable tool for managing insomnia and helping people to get a good night's rest. It's like discovering a new oasis in the desert – a place where rest and rejuvenation can be found.

Restoring Balance in the Desert of Insomnia

This study highlights the importance of finding effective treatments for insomnia. It's like navigating a vast desert – you need to find sources of water and nourishment to stay healthy and strong. Lemborexant offers a potential solution for those struggling with insomnia, helping them to restore balance and improve their overall well-being. It's a reminder that the desert of insomnia can be overcome with the right tools and support.

Dr.Camel's Conclusion

This study is a reminder that even the most challenging deserts can be overcome with the right guidance and support. The researchers have shed light on the potential of lemborexant for treating insomnia, offering a new and promising path for those who struggle to find restful sleep. It's a testament to the ongoing efforts to improve the lives of people with sleep disorders, helping them to reclaim their ability to rest and rejuvenate.

Date :
  1. Date Completed 2023-09-25
  2. Date Revised 2023-10-06
Further Info :

Pubmed ID

37574610

DOI: Digital Object Identifier

10.1016/j.sleep.2023.07.023

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・Effects of lemborexant
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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