The Role of Recipient Thyroid Hormone Supplementation in Primary Graft Dysfunction After Heart Transplantation: A Propensity-Adjusted Analysis.

Author: BrynerBenjamin, CherryAnne, DeVoreAdam, GoslingAndre F, KerrDaryl, McCartneySharon, MilanoCarmelo A, NicoaraAlina, PatelChetan B, PodgoreanuMihai, SchroderJacob N, WrightMary C

Paper Details 
Original Abstract of the Article :
OBJECTIVES: To investigate whether recipient administration of thyroid hormone (liothyronine [T3]) is associated with reduced rates of primary graft dysfunction (PGD) after orthotopic heart transplantation. DESIGN: Retrospective cohort study. SETTING: Single-center, university hospital. PARTICIPA...See full text at original site
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引用元:
https://doi.org/10.1053/j.jvca.2023.07.027

データ提供:米国国立医学図書館(NLM)

Thyroid Hormone Supplementation: A New Oasis in Heart Transplantation?

Heart transplantation, a complex and delicate procedure, is like navigating a challenging desert landscape. This study delves into the role of thyroid hormone supplementation in patients undergoing heart transplantation, focusing on its potential impact on primary graft dysfunction (PGD), a common complication following transplantation. The researchers investigated whether administering the thyroid hormone liothyronine (T3) to recipients could reduce the incidence of PGD.

Thyroid Hormone Supplementation: A Potential Aid in the Desert of Heart Transplantation

The researchers compared two groups of heart transplant recipients: those who received T3 and those who did not. They found that T3 supplementation did not significantly reduce the overall incidence of PGD. However, further analysis revealed that T3 supplementation may have a positive effect on the severity of PGD, with patients receiving T3 being less likely to develop severe PGD, which requires more intensive mechanical circulatory support. This finding is like discovering a hidden spring in the desert, offering potential benefits for certain patients.

Navigating the Desert of Heart Transplantation

This study provides valuable insights into the potential role of thyroid hormone supplementation in heart transplantation. While it does not provide definitive evidence for its use in preventing PGD, it suggests that T3 may play a role in mitigating the severity of this complication. More research is needed to fully understand the complex interplay between thyroid hormone and PGD, but this study offers a promising new direction for exploring potential interventions in the desert of heart transplantation.

Dr.Camel's Conclusion

This study sheds light on the potential role of thyroid hormone supplementation in heart transplantation, offering a glimmer of hope in the desert of PGD. Further research is crucial to fully explore this avenue, but it highlights the importance of personalized medicine in optimizing outcomes for heart transplant recipients.

Date :
  1. Date Completed 2023-10-02
  2. Date Revised 2023-10-02
Further Info :

Pubmed ID

37586950

DOI: Digital Object Identifier

10.1053/j.jvca.2023.07.027

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SNS
PICO Info
in preparation
Languages

English

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