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Systematic review with meta-analysis: Medical therapies for treatment of ulcerative proctitis.

Author: AruljothyAchuthan, CaronBenedicte, DaneseSilvio, HoganMalcolm, JairathVipul, MaChristopher, MacDonaldJohn K, MoranGordon W, NarulaNeeraj, Peyrin BirouletLaurent, SinghSiddharth, VuyyuruSudheer K, ZayadiAlexa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Topical 5-aminosalicylic acid (5-ASA) and corticosteroids are effective for active ulcerative proctitis (UP). Topical 5-ASA may be effective for maintenance of remission. Tacrolimus may be effective for induction of remission. Etrasimod may be effective for induction and for maintenance of remission.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Ulcerative proctitis (UP) is a common highly symptomatic form of ulcerative colitis that can be difficult to treat. AIM: To assess the efficacy of medical treatments for UP. METHODS: We searched MEDLINE, EMBASE, and CENTRAL on 23 November 2022 for randomised controlled trials (RCTs) of...See full text at original site
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引用元：
https://doi.org/10.1111/apt.17666

データ提供：米国国立医学図書館（NLM）

A Comprehensive Review of Medical Therapies for Ulcerative Proctitis

Ulcerative proctitis (UP), a common and often troublesome form of ulcerative colitis, affects the rectum and can be challenging to manage. This systematic review with meta-analysis aimed to assess the efficacy of various medical treatments for UP. The researchers analyzed 53 randomized controlled trials (RCTs) involving 4096 adults with UP. They evaluated the effectiveness of different therapies in inducing and maintaining clinical remission. The findings revealed that topical 5-aminosalicylic acid (5-ASA), conventional corticosteroids, budesonide, and oral 5-ASA were effective first-line therapies for inducing remission. For refractory UP, topical tacrolimus and small molecules like etrasimod showed promise.

Navigating Ulcerative Proctitis Treatment

This comprehensive review provides a valuable guide for managing UP, summarizing the evidence from multiple RCTs. The findings offer insights into the effectiveness of different treatment options, including first-line therapies and those used for refractory cases. It's a reminder that the search for effective and safe treatments for inflammatory bowel diseases is a continuous journey.

Living with Ulcerative Proctitis

The study underscores the importance of seeking appropriate medical care for UP. It emphasizes the availability of effective therapies and highlights the need for personalized treatment approaches based on individual patient needs.

Dr.Camel's Conclusion

This review is a beacon of hope for individuals struggling with UP. It's like a desert oasis, providing a comprehensive overview of treatment options and guiding patients and clinicians towards effective management. The study's findings are a testament to the dedication of researchers and healthcare providers in improving the lives of those affected by inflammatory bowel diseases. It's a reminder that even amidst the challenges of chronic illness, there are effective treatments and ongoing research to provide hope and support.

Date :
  1. Date Completed 2023-09-29
  2. Date Revised 2023-10-10
Further Info :

Pubmed ID

37589498

DOI: Digital Object Identifier

10.1111/apt.17666

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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