Effects of isotretinoin and acitretin on neuroregeneration in experimental spinal cord injury.

Author: KılıçGüven, PolatÖmer, SoyluHakan, ŞensoyDoğan

Paper Details 
Original Abstract of the Article :
OBJECTIVE: This study aimed to determine whether isotretinoin and acitretin have beneficial effects on neural tissue damage following acute spinal cord injury. METHODS: Thirty-six rats were randomly divided into 6 groups: control, sham spinal cord injury, spinal cord injury with isotretinoin 15 mg/...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544667/

データ提供:米国国立医学図書館(NLM)

Isotretinoin and Acitretin: A New Hope for Spinal Cord Injury?

We're all familiar with the saying, "It's a long road to recovery." Well, in the realm of spinal cord injury, that road can feel like a trek across the Sahara Desert! But researchers are always looking for ways to shorten the journey, and a new study has shed light on the potential benefits of isotretinoin and acitretin. This research, published in the journal [Journal Name], delves into the impact of these medications on neural tissue damage following spinal cord injury. The researchers used a combination of experimental methods, including a clip compression technique to induce spinal cord injury in rats, and neurological evaluations to assess functional recovery.

Promising Results for Neuroregeneration

The researchers discovered that both isotretinoin and acitretin demonstrated promising results. The animals treated with these medications showed significant improvements in functional recovery, with increased mobility and reduced neuronal apoptosis, or programmed cell death. This finding suggests that these medications may hold potential as therapeutic agents for treating spinal cord injury.

A Ray of Hope for Patients

These findings offer a glimmer of hope for patients who have suffered spinal cord injuries. While more research is needed to confirm these findings in humans and to determine the optimal dosage and treatment duration, this study is a significant step forward in the search for effective treatments for spinal cord injury. As a researcher, I'm excited about the potential implications of these findings. Maybe one day, the journey across the Sahara Desert of recovery won't feel so daunting.

Dr.Camel's Conclusion

This research explores the potential of isotretinoin and acitretin in promoting neuroregeneration following spinal cord injury. The findings suggest that these medications may play a role in improving functional recovery and reducing neuronal apoptosis. While further research is crucial, this study offers a promising avenue for exploring new therapeutic strategies for treating spinal cord injury.

Date :
  1. Date Completed 2023-09-07
  2. Date Revised 2023-10-04
Further Info :

Pubmed ID

37670445

DOI: Digital Object Identifier

PMC10544667

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Languages

English

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