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A randomized, double-blind, placebo-controlled, crossover study of respiratory safety of lemborexant in moderate-to-severe obstructive sleep apnea.

Author: ChengJocelyn Y, HallNancy, LorchDaniel, LoweAlan D, MolineMargaret, ShahDhara, UchimuraNaohisa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Lemborexant (LEM10) was found to be safe for respiratory function in adults with moderate to severe obstructive sleep apnea (OSA). There were no significant differences in apnea-hypopnea index (AHI) or oxygen saturation between LEM10 and placebo groups. LEM10 may be a treatment option for patients with OSA and comorbid insomnia.
Paper Details　
Original Abstract of the Article :
STUDY OBJECTIVES: To evaluate the respiratory safety of lemborexant among adults and older adults with moderate to severe obstructive sleep apnea (OSA). METHODS: E2006-A001-113 (Study 113; NCT04647383) was a double-blind, two-period crossover, placebo-controlled study in adults (ages ≥ 45 to ≤ 90 y...See full text at original site
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引用元：
https://doi.org/10.5664/jcsm.10788

データ提供：米国国立医学図書館（NLM）

Lemborexant: A Potential Solution for Sleep Apnea and Insomnia

The desert of sleep disorders can be a challenging and exhausting place, filled with conditions like obstructive sleep apnea (OSA) and insomnia. This study, published in the journal Sleep, investigates the respiratory safety of lemborexant, a medication used to treat insomnia, in patients with moderate to severe OSA. This research aims to evaluate the potential benefits and risks of using lemborexant for individuals suffering from both OSA and insomnia.

Lemborexant: A Safe and Effective Approach?

The study found that lemborexant did not significantly affect respiratory function in patients with moderate to severe OSA. This suggests that lemborexant could be a safe and effective treatment option for individuals with both OSA and insomnia, potentially providing relief for both conditions. This research is an important step forward in understanding the potential benefits and risks of using lemborexant for these conditions.

Finding Relief from Sleep Disorders

This research is encouraging for individuals suffering from both OSA and insomnia, offering a potential solution for both conditions. It highlights the importance of individualised treatment plans and the need to carefully consider the potential risks and benefits of different medications.

Dr. Camel's Conclusion

This study offers a glimmer of hope in the vast desert of sleep disorders. By demonstrating the respiratory safety of lemborexant in patients with OSA, the research provides potential relief for those struggling with both OSA and insomnia. Further research is needed, but this study opens up a promising new avenue for treating these challenging conditions.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-09-07
Further Info :

Pubmed ID

37677076

DOI: Digital Object Identifier

10.5664/jcsm.10788

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Article Analysis
・Effects of lemborexant
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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