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The role of lactoferrin in bone remodeling: evaluation of its potential in targeted delivery and treatment of metabolic bone diseases and orthopedic conditions.

Author: HanYing-Bo, LiJin-Long, ShiChang-Sai, TianDan, TianMiao, YangGui-Yun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Lactoferrin (Lf) is a multifunctional protein with diverse biological roles, including bone remodeling. This review discusses Lf's critical functions in regulating osteoblasts, chondrocytes, and osteoclasts, and its potential as a therapeutic target for bone disorders. Lf's signaling pathways, benefits in fracture repair and osteoporosis, and the potential of bioactive peptides derived from Lf are explored.
Paper Details　
Original Abstract of the Article :
Lactoferrin (Lf) is a multifunctional protein that is synthesized endogenously and has various biological roles including immunological regulation, antibacterial, antiviral, and anticancer properties. Recently, research has uncovered Lf's critical functions in bone remodeling, where it regulates the...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482240/

データ提供：米国国立医学図書館（NLM）

Lactoferrin: A Potential New Weapon in Bone Remodeling

This study takes us on a journey through the fascinating world of bone remodeling, exploring the potential of lactoferrin (Lf) – a protein that plays a crucial role in immune defense, as a therapeutic agent. Lf, like a skilled sculptor, influences the activity of bone cells, promoting bone formation and inhibiting bone resorption. It achieves this by activating various signaling pathways in osteoblasts and chondrocytes, while simultaneously suppressing osteoclast activity. This complex interplay of signaling pathways leads to improved bone health and accelerated fracture healing, as demonstrated in animal studies.

Lf's Role in Bone Remodeling

The study highlights the remarkable ability of Lf to modulate bone remodeling. It effectively stimulates osteoblast and chondrocyte activity, while simultaneously inhibiting osteoclast function. This balancing act contributes to accelerated fracture repair and potentially offers a novel therapeutic approach for treating metabolic bone diseases like osteoporosis.

Promising Therapeutic Potential for Bone Health

Lf's potential as a therapeutic agent for bone disorders is promising. Its ability to stimulate bone formation and inhibit bone resorption could revolutionize the treatment of osteoporosis and other bone-related conditions. However, Lf's large size poses a challenge for drug delivery. Further research is needed to develop effective delivery strategies that target the active concentration of Lf to the site requiring bone regeneration.

Dr. Camel's Conclusion

This research unveils the intricate role of lactoferrin in bone remodeling and its potential as a therapeutic target for bone disorders. While further research is needed to overcome delivery challenges, Lf's ability to influence bone health offers exciting possibilities for treating metabolic bone diseases and accelerating fracture healing.
Date :
  1. Date Completed 2023-09-11
  2. Date Revised 2023-09-11
Further Info :

Pubmed ID

37680888

DOI: Digital Object Identifier

PMC10482240

Related Literature

Article Analysis
・Effective treatment of bone diseases
SNS
PICO Info
in preparation
Languages

English

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