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SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes.

Author: LiuJuli, LiuSheng, WanJun, WangCheng, WuShiyong, YangLei, ZhangYucheng

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study elucidates the deleterious effects of SARS-CoV-2 genes Nsp6, M, and Nsp8 on human cardiomyocytes (CMs), contributing to a better understanding of the virus's impact on cardiovascular health and its role in COVID-19 mortality.
Paper Details　
Original Abstract of the Article :
Cardiovascular complications significantly augment the overall COVID-19 mortality, largely due to the susceptibility of human cardiomyocytes (CMs) to SARS-CoV-2 virus. SARS-CoV-2 virus encodes 27 genes, whose specific impacts on CM health are not fully understood. This study elucidates the deleterio...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500938/

データ提供：米国国立医学図書館（NLM）

The Heart of the Storm: SARS-CoV-2's Impact on Cardiomyocytes

The COVID-19 pandemic has brought a storm of challenges to the world, impacting the heart in ways we are still uncovering. This study explores the specific effects of SARS-CoV-2 genes Nsp6, M, and Nsp8 on human cardiomyocytes (CMs), revealing a complex interplay that can compromise cellular function and survival. The researchers use pluripotent stem cell-derived cardiomyocytes to study the impact of these genes on the heart.

A Devastating Assault: SARS-CoV-2's Attack on the Heart

The study identifies a devastating impact of these SARS-CoV-2 genes on human CMs, leading to compromised cellular ATP levels and impaired survival. It's like a relentless desert wind that saps the strength of a weary traveler, leaving them vulnerable to the harsh environment.

A New Frontier: Understanding the Heart's Response to COVID-19

This research provides valuable insights into the specific mechanisms by which SARS-CoV-2 affects the heart, paving the way for the development of targeted therapies to mitigate the cardiovascular complications of COVID-19. It's like mapping a new territory in the desert, uncovering the secrets of a previously unknown landscape.

Dr. Camel's Conclusion

This study sheds light on the devastating impact of specific SARS-CoV-2 genes on human cardiomyocytes, revealing a complex mechanism that compromises cellular function and survival. This research highlights the need for further investigation into the cardiovascular implications of COVID-19, paving the way for the development of targeted therapies to protect the heart from the storm of this pandemic.

Date :
  1. Date Completed 2023-09-15
  2. Date Revised 2023-11-23
Further Info :

Pubmed ID

37705046

DOI: Digital Object Identifier

PMC10500938

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Languages

English

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