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Meclizine moderates lipopolysaccharide-induced neuroinflammation in mice through the regulation of AKT/ NF-κβ/ERK/JNK signaling pathway.

Author: AsaadGihan F, MostafaRasha E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the neuroprotective effects of meclizine (MCLZ) against lipopolysaccharide (LPS)-induced neuroinflammation in mice. MCLZ effectively reduced inflammation and downregulated several signaling pathways associated with neuroinflammation, suggesting its potential as a treatment option.
Paper Details　
Original Abstract of the Article :
Neuroinflammation is identified as significant inflammatory reactions occurring in the central nervous system. Lipopolysaccharide (LPS) stimulates innate immune reactions and is used as an in vivo animal model for the investigation of inflammation. Meclizine (MCLZ) is a histamine antagonist with pot...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663243/

データ提供：米国国立医学図書館（NLM）

Meclizine: A Potential Oasis in the Desert of Neuroinflammation

Neuroinflammation is a complex and often debilitating condition, like a sandstorm raging within the delicate oasis of the brain. This research delves into the potential neuroprotective effects of meclizine, a histamine antagonist, against neuroinflammation induced by lipopolysaccharide (LPS). The researchers found that meclizine effectively downregulated various inflammatory markers in the brains of mice treated with LPS, suggesting a protective effect against neuroinflammation.

A New Perspective on Neuroinflammation

The study demonstrates meclizine's ability to moderate neuroinflammation through its regulation of the AKT/NF-κβ/ERK/JNK signaling pathway. This discovery opens new avenues for exploring the potential therapeutic applications of meclizine in managing neuroinflammatory conditions.

Navigating Neuroinflammation with Caution

While this research suggests a potential role for meclizine in neuroinflammation, it’s important to remember that these are early findings. More research is needed to understand the full therapeutic potential and potential side effects of meclizine for neuroinflammation. Always consult with a qualified healthcare professional for personalized advice.

Dr. Camel's Conclusion

This study is like a small oasis in the vast desert of neuroinflammation research. It offers promising insights into the potential of meclizine as a neuroprotective agent. However, further studies are crucial to confirm its efficacy and safety for treating neuroinflammatory conditions.

Date :
  1. Date Completed 2023-11-27
  2. Date Revised 2023-11-27
Further Info :

Pubmed ID

37733253

DOI: Digital Object Identifier

PMC10663243

Related Literature

Article Analysis
・Effects of meclizine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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