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Dextromethorphan-Bupropion for the Treatment of Depression: A Systematic Review of Efficacy and Safety in Clinical Trials.

Author: AkbarDania, CaoBing, CebanFelicia, HoRoger, KwanAngela T H, McIntyreRoger S, RheeTaeho Greg, RosenblatJoshua D, SubramaniapillaiMehala, TeopizKayla M

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The combination of dextromethorphan and bupropion (AXS-05) is a well-tolerated, rapid-acting treatment option for adults with major depressive disorder (MDD). This combination significantly reduced depression severity and improved clinical remission and response rates.
Paper Details　
Original Abstract of the Article :
BACKGROUND: A significant proportion of adults with major depressive disorder (MDD) do not respond to treatments which are currently used in clinical practice such as first-generation monoamine-based antidepressants. OBJECTIVES: The objective of this systematic review was to assess the efficacy, sa...See full text at original site
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引用元：
https://doi.org/10.1007/s40263-023-01032-5

データ提供：米国国立医学図書館（NLM）

Dextromethorphan-Bupropion: A New Path Through the Desert of Depression

Major Depressive Disorder (MDD) affects millions worldwide, and finding effective treatments can be a daunting task. This systematic review explores the efficacy and safety of AXS-05, a combination of dextromethorphan and bupropion, in treating MDD. The researchers, like explorers seeking a new route through a vast desert, analyzed clinical trials evaluating the effectiveness of AXS-05. Their findings suggest that AXS-05 may be a well-tolerated, rapid-acting treatment option for MDD, offering a potential new path for individuals struggling with this debilitating condition.

AXS-05: A Promising Oasis in the Desert of Depression

This systematic review suggests that AXS-05, a combination of dextromethorphan and bupropion, may be a well-tolerated and rapid-acting treatment option for MDD. This research, like a desert explorer finding a hidden oasis, highlights the potential of AXS-05 to offer hope and relief to individuals struggling with this condition. It underscores the importance of continuing to explore innovative approaches to treat depression.

Navigating the Desert of Mental Health

This research provides a glimmer of hope for individuals struggling with MDD, suggesting that AXS-05 may be a well-tolerated and effective treatment option. It's like finding a new path through a vast and often challenging desert, offering a sense of relief and a brighter outlook. It's important to consult with a healthcare professional to determine the best treatment approach based on individual needs and preferences.

Dr.Camel's Conclusion

This systematic review suggests that AXS-05, a combination of dextromethorphan and bupropion, may be a well-tolerated and rapid-acting treatment option for MDD, offering hope for individuals struggling with this condition. It's like discovering a hidden oasis in the desert, a place of healing and renewal. It's important to remember that mental health is just as crucial as physical health, and seeking appropriate treatment can be a life-changing decision.

Date :
  1. Date Completed 2023-11-01
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

37792265

DOI: Digital Object Identifier

10.1007/s40263-023-01032-5

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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