Phase 1/1b open-label, dose-escalation study of fruquintinib in patients with advanced solid tumors in the United States.

Author: ChienCaly, GonzalezMartha, KaniaMarek, SchelmanWilliam, UkrainskyjStacey, Wang-GillamAndrea, YangZhao, Yeckes-RodinHeather

Paper Details 
Original Abstract of the Article :
This open-label, phase 1/1b study was conducted to evaluate the safety, tolerability, and pharmacokinetics (PK) of fruquintinib in United States (U.S.) patients to confirm the recommended phase 2 dose (RP2D) established in China. Patients with advanced solid tumors who had progressed on approved sys...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663261/

データ提供:米国国立医学図書館(NLM)

Fruquintinib: A Promising New Agent for Advanced Solid Tumors

The fight against advanced solid tumors is an ongoing challenge for oncologists and patients alike. This phase 1/1b study investigates the safety, tolerability, and pharmacokinetics (PK) of fruquintinib, a novel tyrosine kinase inhibitor, in patients with advanced solid tumors. The researchers aimed to confirm the recommended phase 2 dose (RP2D) of fruquintinib in United States patients, building upon previous studies conducted in China.

Fruquintinib: Safety, Tolerability, and Preliminary Antitumor Activity

The study confirmed the RP2D of fruquintinib to be 5 mg once daily, administered in a 3 weeks on/1 week off schedule. Fruquintinib was generally well tolerated, with manageable side effects. Preliminary anticancer activity was observed, suggesting potential therapeutic benefits for patients with advanced solid tumors.

A New Weapon in the Arsenal Against Solid Tumors

This research offers hope for patients with advanced solid tumors, presenting fruquintinib as a promising new therapeutic option. While further studies are needed to fully evaluate its effectiveness and long-term safety, the initial findings are encouraging. Consulting with a healthcare professional is essential for discussing personalized treatment plans and managing potential side effects.

Dr.Camel's Conclusion

The desert of cancer research is vast and demanding, but new discoveries are constantly emerging. Fruquintinib, like a beacon of hope in the desert, shows promise as a potential treatment for advanced solid tumors. While further research is needed, these initial findings offer encouragement for patients seeking new treatment options. Remember, seeking expert medical guidance is crucial for navigating the complex landscape of cancer therapy.

Date :
  1. Date Completed 2023-11-22
  2. Date Revised 2023-11-24
Further Info :

Pubmed ID

37796398

DOI: Digital Object Identifier

PMC10663261

Related Literature

SNS
PICO Info
in preparation
Languages

English

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