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A comparative study of two beta-blocker-diuretic combinations in the treatment of hypertension.

Author: LubisH R, SilalahiM, Yushar

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Both propranolol/hydrochlorothiazide and acebutolol/hydrochlorothiazide combinations were effective in reducing blood pressure in patients with essential hypertension. The acebutolol combination produced a significantly greater reduction in diastolic blood pressure.
Paper Details　
Original Abstract of the Article :
Twenty patients with mild to severe essential hypertension completed a 12-week open crossover study to compare the effectiveness and tolerance of two beta-blocker/diuretic combinations. Patients were allocated at random to receive treatment for 6 weeks with either 40 mg propranolol plus 12.5 mg hydr...See full text at original site
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引用元：
https://doi.org/10.1185/03007998609110442

データ提供：米国国立医学図書館（NLM）

Beta-Blocker/Diuretic Combinations: A Comparison for Hypertension

This research investigates the effectiveness and tolerability of two beta-blocker/diuretic combinations in treating hypertension. The study involved 20 patients with mild to severe essential hypertension who participated in a 12-week open crossover trial. Patients were randomly assigned to receive either propranolol plus hydrochlorothiazide or acebutolol plus hydrochlorothiazide for 6 weeks, followed by a crossover to the alternative medication for another 6 weeks. Blood pressure and pulse rate were monitored at regular intervals, along with side effects and laboratory variables.

Acebutolol Combination Shows Greater Effectiveness for Diastolic Blood Pressure

The study found that both drug combinations produced significant reductions in systolic and diastolic blood pressure, but the acebutolol combination resulted in a significantly greater reduction in diastolic blood pressure. Both treatments were generally well-tolerated, with a slight trend favoring the acebutolol combination. The study highlights the importance of individualized treatment approaches in managing hypertension.

Hypertension Management: Finding the Right Combination for You

This study emphasizes the need for careful consideration of treatment options for hypertension. The findings suggest that the acebutolol/hydrochlorothiazide combination may be more effective in lowering diastolic blood pressure. The study highlights the importance of consulting with a healthcare professional to determine the best treatment approach based on individual needs and preferences.

Dr. Camel's Conclusion

This research compares the efficacy and tolerability of two beta-blocker/diuretic combinations for managing hypertension. The findings suggest that the acebutolol combination may provide a more effective reduction in diastolic blood pressure. It underscores the importance of individualizing treatment approaches to achieve optimal blood pressure control.
Date :
  1. Date Completed 1987-01-14
  2. Date Revised 2019-09-08
Further Info :

Pubmed ID

3780286

DOI: Digital Object Identifier

10.1185/03007998609110442

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SNS
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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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