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Safety and Immunogenicity of Live Viral Vaccines in a Multicenter Cohort of Pediatric Transplant Recipients.

Author: AliSaira A, BeatyBrenda L, BitterfeldLeandra, BoulwareMary Alice, CampbellKathleen M, CarrEmily, ChangYeh-Chung, ChapmanShelley, CunninghamRyan, DallasRonald H, DantuluriKeerti L, Danziger-IsakovLara A, DomenickBryanna N, EbelNoelle H, ElisofonScott, FawazRima, FeldmanAmy G, FerrolinoJose A, FocaMarc, GansHayley A, GopalareddyVani V, GuCindy, GuptaNitika A, HarmannKatherine, HollenbeckJessica, HupplerAnna R, JaramilloCatalina, KasiNagraj, KerkarNanda, LerretStacee, LobrittoSteven J, LopezMaclovio J, MariniElizabeth, MaronGabriela, MavisAlisha, MehraSonia, MoatsLynnette, MohandasSindhu, MunozFlor M, MysoreKrupa R, OnsanCeren, OvchinskyNadia, PerkinsKerrigan, PostmaStacy, PratscherLauren, RandElizabeth B, RoweRegina K, SchultzDanielle, SearKatherine, SellMegan L, SharmaTanvi, StollJanis, VangMychoua, VillarinDominique, WeaverCarly, WeidnerHillary K, WoodPhoebe, Woodford-BerryOlivia, YanniGeorge

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Live vaccines such as MMR and VZV have not been routinely recommended after solid organ transplantation due to concerns about vaccine-strain infection in immunocompromised individuals. However, rising rates of vaccine-preventable diseases necessitate reevaluation of this practice to protect vulnerable populations.
Paper Details　
Original Abstract of the Article :
Live vaccines (measles-mumps-rubella [MMR] and varicella-zoster virus [VZV]) have not been recommended after solid organ transplant due to concern for inciting vaccine strain infection in an immunocompromised host. However, the rates of measles, mumps, and varicella are rising nationally and interna...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570873/

データ提供：米国国立医学図書館（NLM）

Navigating the Safety and Immunogenicity of Live Viral Vaccines in Transplant Recipients

In the realm of [immunology], the [use of live viral vaccines] in [immunocompromised individuals], particularly [pediatric transplant recipients], presents a complex challenge. This study addresses this challenge by investigating the [safety and immunogenicity] of [measles-mumps-rubella (MMR) and varicella-zoster virus (VZV)] vaccines in a [multicenter cohort] of [pediatric transplant recipients]. The researchers found that [live viral vaccines can be safely administered to pediatric transplant recipients], providing important insights into the management of [vaccine-preventable diseases] in this vulnerable population.

Safeguarding Transplant Recipients: A Step Forward in Vaccination

The study's results highlight the importance of [individualized risk-benefit assessments] when considering [live viral vaccination] in [transplant recipients]. The researchers demonstrate that [live viral vaccines can be safely administered under specific circumstances], opening up new possibilities for protecting these individuals from [vaccine-preventable diseases]. This research contributes significantly to the development of evidence-based guidelines for vaccination in this population.

A Stronger Immune System for Transplant Recipients

This study provides reassurance that [live viral vaccines can be safely used to strengthen the immune system] of [pediatric transplant recipients]. This can help protect them from [life-threatening conditions] associated with [vaccine-preventable diseases]. While it is crucial to consider individual factors and risks, the study offers a ray of hope for improving the health and well-being of this vulnerable population.

Dr.Camel's Conclusion

Imagine a delicate desert flower, thriving amidst the harsh conditions of the desert. Similarly, transplant recipients are fragile individuals whose immune systems require careful consideration. This research, like a gentle rain nourishing the desert flower, highlights the importance of individualized care and the potential of safe and effective vaccination strategies for protecting these individuals from preventable illnesses. The study's findings provide valuable insights for improving the long-term health and well-being of transplant recipients, ensuring that they can bloom and thrive in the challenging landscape of their journey.
Date :
  1. Date Completed 2023-10-23
  2. Date Revised 2023-10-25
Further Info :

Pubmed ID

37824141

DOI: Digital Object Identifier

PMC10570873

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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