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Screening of natural extracts with anti-norovirus effects and analysis of this mechanism in grape seed extract.
Author: MoritaTakayuki, NishitaniKota, SetoYoshiyuki
Original Abstract of the Article :
Norovirus (NoV）is a major causative virus of viral gastroenteritis and requires a general disinfection method because it is resistant to common disinfectants such as ethanol and chlorhexidine. This study aimed to find natural extracts as candidates for versatile disinfectant ingredients. The antivir...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.4265/jmc.28.3_83
データ提供：米国国立医学図書館（NLM）
Screening of Natural Extracts with Anti-Norovirus Effects: Focus on Grape Seed Extract
The field of [virology] is constantly searching for effective ways to combat [norovirus (NoV)], a leading cause of viral gastroenteritis. This study investigated the potential of natural extracts to inactivate NoV. The researchers screened 63 natural extracts using two methods: the feline calicivirus (FCV) inactivation test and the NoV virus-like particle (NoV-VLP) binding inhibition test. They identified 14 extracts with significant anti-NoV effects. The study focused on grape seed extract (GSE) containing proanthocyanidins, demonstrating a concentration- and time-dependent NoV-VLP binding inhibitory effect. Electron microscopy revealed that GSE treatment caused aggregation, distortion, and swelling of NoV-VLPs, suggesting a direct interaction with the virus particles. The findings suggest that natural extracts, particularly those containing GSE, could hold promise as components of disinfectants against NoV.
Natural Extracts as Potential Anti-Norovirus Agents
This study identifies several natural extracts with potential anti-norovirus effects, particularly grape seed extract. The findings suggest that these extracts could be valuable components of disinfectants, helping to combat the spread of norovirus.
Harnessing Nature's Power to Combat Norovirus
As a seasoned traveler through the vast desert of medical knowledge, I am always intrigued by the potential of natural remedies. This study highlights the exciting possibility of harnessing nature's power to combat norovirus infections. The researchers' findings offer a promising avenue for developing new and effective disinfectants based on natural extracts.
Dr.Camel's Conclusion
This study provides evidence for the potential of natural extracts, particularly grape seed extract, as anti-norovirus agents. The findings suggest that these extracts could be valuable components of disinfectants, offering a new and promising approach to combating the spread of norovirus infections.
Date :
- Date Completed 2023-11-01
- Date Revised 2023-11-01
Further Info :
Related Literature
English
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