Effective treatment of grape seed extract: A Synthesis of Findings from 16 Studies

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Original Abstract of the Article

Major Research Findings

Grape seed extract (GSE) is a natural ingredient with various health benefits, such as antioxidant and anti-inflammatory effects. In recent years, many studies have been conducted on the various effects of GSE. 4 showed that GSE may have antiviral effects against norovirus. GSE was shown to cause agglutination, distortion, and swelling of norovirus-like particles (NoV-VLPs), suggesting that GSE directly interacts with virus particles. 5 demonstrated that feta cheese supplemented with GSE has the effect of inhibiting lipid oxidation. 6 showed that GSE may affect condylar growth in the rat mandible. 7 demonstrated that active films made with pullulan polysaccharide/xanthan gum supplemented with GSE extend the shelf life of apples. 8 showed that GSE has neuroprotective effects in a rat model of malathion-induced neurotoxicity. 9 indicated that GSE may contribute to improving endurance performance in basketball players. 10 showed that GSE may promote hippocampal neurogenesis and synaptogenesis in aged mice, improving memory. 11 demonstrated that GSE has the effect of suppressing aortic stiffness in obese men. 12 showed that GSE enhanced the fertility-enhancing effect of atorvastatin in a rat model of high-fat diet-induced testicular injury. 13 showed that GSE has the effect of inhibiting the proliferation and apoptosis of chemo-resistant ovarian cancer cells. 14 showed that GSE has the effect of lowering blood pressure in both normal weight and obese men. 15 showed that GSE has the effect of enhancing antioxidant activity and inhibiting the accumulation of diacylglycerols and ceramides in the liver in a rat model of high-fat, high-sugar diet-induced insulin resistance. 16 showed that GSE had growth-promoting, immune-enhancing, antioxidant, and meat quality-improving effects in Pekin ducks. 2 demonstrated that GSE has the effect of promoting wound healing. 1 showed that GSE has the effect of lowering blood pressure and heart rate. 3 showed that GSE may affect inflammatory markers, neuropeptide Y, anthropometric measures, and appetite in obese or overweight individuals.

Benefits and Risks

Benefits Summary

Grape seed extract is expected to have various health benefits. Many studies have reported various effects, such as antioxidant and anti-inflammatory effects, antiviral effects against norovirus, lipid oxidation inhibitory effects, wound healing promoting effects, and blood pressure and heart rate lowering effects.

Risks Summary

Grape seed extract is generally considered safe, but some people may experience side effects. Side effects reported include digestive symptoms (stomach pain, diarrhea, etc.), allergic reactions, and low blood pressure. Pregnant or breastfeeding women, people taking medications, and those with certain medical conditions should consult a doctor before taking grape seed extract.

Comparison of Studies

Commonalities of Studies

Many studies have shown that grape seed extract has antioxidant and anti-inflammatory properties. In addition, GSE has shown potential benefits for various diseases and conditions.

Differences in Studies

The effects of GSE vary from study to study, and the magnitude of the effects may vary depending on the extraction method, concentration, dosage, and subject. Also, research on the effects of GSE is not yet fully conducted, so further research is needed on the safe dosage and long-term effects of GSE.

Consistency and Contradictions in Results

There are some consistent results regarding GSE, but there are also some contradictory results. Further research is needed to fully understand the various effects of GSE.

Precautions for Real-World Applications

GSE is available in food and supplement forms. When taking GSE, it is important to carefully check the product label and take an appropriate amount. Also, pregnant or breastfeeding women, people taking medications, and those with certain medical conditions should consult a doctor before taking GSE.

Limitations of Current Research

Research on GSE is still in its early stages. In particular, further research is needed on the long-term effects and safe dosage of GSE.

Future Research Directions

Further research is needed to gain a deeper understanding of the various effects of GSE. In particular, research should be conducted on the long-term effects and safe dosage of GSE, its effects on various diseases and conditions, and its interactions with other medications.

Conclusion

Grape seed extract is a natural ingredient with various health benefits. Many studies have shown its effectiveness, such as antioxidant and anti-inflammatory effects. However, research on GSE is still in its early stages, so further research is needed. When taking GSE, it is important to carefully check the product label and take an appropriate amount. Also, pregnant or breastfeeding women, people taking medications, and those with certain medical conditions should consult a doctor before taking GSE.

Literature analysis of 16 papers
Positive Content
15
Neutral Content
1
Negative Content
0
Article Type
3
1
1
1
16
1.

The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials.

Author: FeringaHarm H H, LaskeyDayne A, DicksonJustine E, ColemanCraig I

Improved cardiovascular health

This systematic review assessed the effects of grape seed extract on blood pressure, heart rate, lipid levels, and C-reactive protein (CRP) levels. The meta-analysis found that grape seed extract significantly lowered systolic blood pressure and heart rate but did not affect lipid or CRP levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

The topical effect of grape seed extract 2% cream on surgery wound healing.

Author: HemmatiAli Asghar, ForoozanMaryam, HoushmandGholamreza, MoosaviZahra Beigom, BahadoramMohammad, MaramNader Shakiba

Grape seed extract
Wound healing

Grape seed extract 2% herbal cream was found to be effective in promoting wound healing and may offer a natural alternative for treating skin lesions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

The effects of grape seed extract (Vitis vinifera) supplement on inflammatory markers, neuropeptide Y, anthropometric measures, and appetite in obese or overweight individuals: A randomized clinical trial.

Author: ParandooshMaryam, YousefiReyhaneh, KhorsandiHoda, NikpayamOmid, SaidpourAtoosa, BabaeiHossein

This study investigates the effects of grape seed extract (GSE) supplementation on inflammatory markers, neuropeptide Y, anthropometric measurements, and appetite in obese or overweight individuals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Effects of Grape Seed Extract Supplementation on Endothelial Function and Endurance Performance in Basketball Players.

Author: NhoHosung, KimKyung-Ae

Endothelial Function
Endurance Performance

Chronic supplementation with grape seed extract (GSE) containing high doses of polyphenols improved endurance performance in elite athletes, possibly due to enhanced endothelial function. GSE decreased submaximal VO2 and increased time to exhaustion compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Effects of chronic dietary grape seed extract supplementation on aortic stiffness and hemodynamic responses in obese/overweight males during submaximal exercise.

Author: DillonKatherine, ShariffiBrian, GillumTrevor, BoyerWilliam, SullivanSean, KimJong-Kyung

Aortic stiffness
Blood pressure

This study investigated the effect of chronic grape seed extract (GSE) on blood pressure and aortic stiffness (AoS) in overweight and obese males. Results showed that GSE supplementation significantly reduced MAP at rest and during exercise, primarily due to a substantial reduction in AoS. These findings suggest that GSE may be a useful dietary supplement for managing blood pressure in obese and overweight males.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Anti-proliferative and anti-apoptotic effects of grape seed extract on chemo-resistant OVCAR-3 ovarian cancer cells.

Author: HomayounMansour, Ghasemnezhad TarghiReza, SoleimaniMitra

Chemo-resistance inhibition

This study investigates the effects of grape seed extract (GSE) on OVCAR-3, a chemo-resistant ovarian cancer cell line.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Effects of Acute Grape Seed Extract Supplementation on Hemodynamics in Normal Body Weight and Obese Males.

Author: DillonKatherine N, ShariffiBrian, ThompsonBrittany, SteeleRichard, KimJong-Kyung

GSE aortic stiffness reduction
GSE blood pressure reduction

This study investigated the effects of acute grape seed extract (GSE) supplementation on blood pressure and aortic stiffness in obese and normal-weight individuals. GSE supplementation significantly reduced systolic and mean arterial pressure in both groups, possibly by reducing cardiac output in obese individuals and peripheral vasoconstriction in normal-weight individuals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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